Entity Details

Primary name ERBB3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP21860
EntryNameERBB3_HUMAN
FullNameReceptor tyrosine-protein kinase erbB-3
TaxID9606
Evidenceevidence at protein level
Length1342
SequenceStatuscomplete
DateCreated1991-05-01
DateModified2021-06-02

Ontological Relatives

GenesERBB3

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0003197 endocardial cushion development
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005524 ATP binding
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007162 negative regulation of cell adhesion
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0007399 nervous system development
GO:0007422 peripheral nervous system development
GO:0007507 heart development
GO:0008284 positive regulation of cell population proliferation
GO:0009925 basal plasma membrane
GO:0009968 negative regulation of signal transduction
GO:0010628 positive regulation of gene expression
GO:0014037 Schwann cell differentiation
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0016328 lateral plasma membrane
GO:0019838 growth factor binding
GO:0021545 cranial nerve development
GO:0030296 protein tyrosine kinase activator activity
GO:0031625 ubiquitin protein ligase binding
GO:0033674 positive regulation of kinase activity
GO:0038128 ERBB2 signaling pathway
GO:0038131 neuregulin receptor activity
GO:0038132 neuregulin binding
GO:0038143 ERBB3:ERBB2 complex
GO:0042060 wound healing
GO:0042127 regulation of cell population proliferation
GO:0042802 identical protein binding
GO:0043125 ErbB-3 class receptor binding
GO:0043235 receptor complex
GO:0043524 negative regulation of neuron apoptotic process
GO:0046982 protein heterodimerization activity
GO:0051048 negative regulation of secretion
GO:0051402 neuron apoptotic process
GO:0051897 positive regulation of protein kinase B signaling
GO:0055025 positive regulation of cardiac muscle tissue development
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0070886 positive regulation of calcineurin-NFAT signaling cascade
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:2000145 regulation of cell motility

Subcellular Location

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Subcellular Location
Cell membrane
Secreted

Domains

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DomainNameCategoryType
IPR000494 Receptor L-domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR006211 Furin-like cysteine-rich domainDomainDomain
IPR006212 Furin-like repeatRepeatRepeat
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR016245 Tyrosine protein kinase, EGF/ERB/XmrK receptorFamilyFamily
IPR032778 Growth factor receptor domain 4DomainDomain
IPR036941 Receptor L-domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB11652 TucatinibDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
ERBB3_HUMANSHC1_MOUSEBioGRID9694850 details