Entity Details

Primary name FGFR3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP22607
EntryNameFGFR3_HUMAN
FullNameFibroblast growth factor receptor 3
TaxID9606
Evidenceevidence at protein level
Length806
SequenceStatuscomplete
DateCreated1991-08-01
DateModified2021-06-02

Ontological Relatives

GenesFGFR3

GO terms

Show/Hide Table
GOName
GO:0000165 MAPK cascade
GO:0001501 skeletal system development
GO:0001958 endochondral ossification
GO:0002062 chondrocyte differentiation
GO:0003416 endochondral bone growth
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005007 fibroblast growth factor-activated receptor activity
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007267 cell-cell signaling
GO:0007275 multicellular organism development
GO:0008284 positive regulation of cell population proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009986 cell surface
GO:0010518 positive regulation of phospholipase activity
GO:0017134 fibroblast growth factor binding
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030133 transport vesicle
GO:0030282 bone mineralization
GO:0033674 positive regulation of kinase activity
GO:0035988 chondrocyte proliferation
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042802 identical protein binding
GO:0043235 receptor complex
GO:0043410 positive regulation of MAPK cascade
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0046777 protein autophosphorylation
GO:0048640 negative regulation of developmental growth
GO:0051897 positive regulation of protein kinase B signaling
GO:0060349 bone morphogenesis
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070977 bone maturation
GO:1902178 fibroblast growth factor receptor apoptotic signaling pathway

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane
Cytoplasmic vesicle
Endoplasmic reticulum
Secreted

Domains

Show/Hide Table
DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013098 Immunoglobulin I-setDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR016248 Fibroblast growth factor receptor familyFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily
IPR041159 Fibroblast growth factor receptor, transmembrane domainDomainDomain

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB05014 XL999Drugbanksmall molecule
DB06589 PazopanibDrugbanksmall molecule
DB08901 PonatinibDrugbanksmall molecule
DB09078 LenvatinibDrugbanksmall molecule
DB09079 NintedanibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB12147 ErdafitinibDrugbanksmall molecule
DB15102 PemigatinibDrugbanksmall molecule
DB15685 SelpercatinibDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
FGFR3_HUMANSH2B1_MOUSEBioGRID11827956 details