Entity Details

Primary name CBL_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP22681
EntryNameCBL_HUMAN
FullNameE3 ubiquitin-protein ligase CBL
TaxID9606
Evidenceevidence at protein level
Length906
SequenceStatuscomplete
DateCreated1991-08-01
DateModified2021-06-02

Ontological Relatives

GenesCBL

GO terms

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GOName
GO:0000209 protein polyubiquitination
GO:0001784 phosphotyrosine residue binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005154 epidermal growth factor receptor binding
GO:0005509 calcium ion binding
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0005929 cilium
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006513 protein monoubiquitination
GO:0006974 cellular response to DNA damage stimulus
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007175 negative regulation of epidermal growth factor-activated receptor activity
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0008584 male gonad development
GO:0010332 response to gamma radiation
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014823 response to activity
GO:0016567 protein ubiquitination
GO:0016600 flotillin complex
GO:0017124 SH3 domain binding
GO:0019221 cytokine-mediated signaling pathway
GO:0030426 growth cone
GO:0030971 receptor tyrosine kinase binding
GO:0032487 regulation of Rap protein signal transduction
GO:0033574 response to testosterone
GO:0035635 entry of bacterium into host cell
GO:0036120 cellular response to platelet-derived growth factor stimulus
GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0042594 response to starvation
GO:0043066 negative regulation of apoptotic process
GO:0043303 mast cell degranulation
GO:0045121 membrane raft
GO:0045296 cadherin binding
GO:0045471 response to ethanol
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway
GO:0046677 response to antibiotic
GO:0046875 ephrin receptor binding
GO:0048260 positive regulation of receptor-mediated endocytosis
GO:0048471 perinuclear region of cytoplasm
GO:0061024 membrane organization
GO:0061630 ubiquitin protein ligase activity
GO:0070102 interleukin-6-mediated signaling pathway
GO:0070997 neuron death
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0090650 cellular response to oxygen-glucose deprivation
GO:1901215 negative regulation of neuron death
GO:1990090 cellular response to nerve growth factor stimulus
GO:2000583 regulation of platelet-derived growth factor receptor-alpha signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Cytoplasm
Golgi apparatus

Domains

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DomainNameCategoryType
IPR001841 Zinc finger, RING-typeDomainDomain
IPR003153 Adaptor protein Cbl, N-terminal helicalDomainDomain
IPR009060 UBA-like superfamilyFamilyHomologous superfamily
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR014741 Adaptor protein Cbl, EF hand-likeDomainDomain
IPR014742 Adaptor protein Cbl, SH2-like domainDomainDomain
IPR015940 Ubiquitin-associated domainDomainDomain
IPR017907 Zinc finger, RING-type, conserved siteSiteConserved site
IPR024159 Adaptor protein Cbl, PTB domainDomainDomain
IPR024162 Adaptor protein CblFamilyFamily
IPR036537 Adaptor protein Cbl, N-terminal domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily
IPR039520 E3 ubiquitin-protein ligase CBL-B, RING finger, HC subclassDomainDomain

Diseases

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