Entity Details

Primary name JAK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP23458
EntryNameJAK1_HUMAN
FullNameTyrosine-protein kinase JAK1
TaxID9606
Evidenceevidence at protein level
Length1154
SequenceStatuscomplete
DateCreated1991-11-01
DateModified2021-06-02

Ontological Relatives

GenesJAK1

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005131 growth hormone receptor binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005925 focal adhesion
GO:0006468 protein phosphorylation
GO:0016020 membrane
GO:0019221 cytokine-mediated signaling pathway
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0031730 CCR5 chemokine receptor binding
GO:0034112 positive regulation of homotypic cell-cell adhesion
GO:0035556 intracellular signal transduction
GO:0035722 interleukin-12-mediated signaling pathway
GO:0035723 interleukin-15-mediated signaling pathway
GO:0038110 interleukin-2-mediated signaling pathway
GO:0038111 interleukin-7-mediated signaling pathway
GO:0038113 interleukin-9-mediated signaling pathway
GO:0038114 interleukin-21-mediated signaling pathway
GO:0046677 response to antibiotic
GO:0046872 metal ion binding
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060334 regulation of interferon-gamma-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
GO:0070102 interleukin-6-mediated signaling pathway
GO:0070106 interleukin-27-mediated signaling pathway
GO:0070757 interleukin-35-mediated signaling pathway
GO:0150105 protein localization to cell-cell junction
GO:1903672 positive regulation of sprouting angiogenesis

Subcellular Location

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Subcellular Location
Endomembrane system

Domains

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DomainNameCategoryType
IPR000299 FERM domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR016251 Tyrosine-protein kinase, non-receptor Jak/Tyk2FamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR019748 FERM central domainDomainDomain
IPR019749 Band 4.1 domainDomainDomain
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR020776 Tyrosine-protein kinase, non-receptor Jak1FamilyFamily
IPR035963 FERM superfamily, second domainFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily
IPR041046 JAK, FERM F2 lobe domainDomainDomain
IPR041155 FERM F1 lobe ubiquitin-like domainDomainDomain
IPR041381 Jak1, pleckstrin homology-like domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB02375 MyricetinDrugbanksmall molecule
DB04716 2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-oneDrugbanksmall molecule
DB08877 RuxolitinibDrugbanksmall molecule
DB08895 TofacitinibDrugbanksmall molecule
DB11817 BaricitinibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB12500 FedratinibDrugbanksmall molecule
DB14845 FilgotinibDrugbanksmall molecule
DB15091 UpadacitinibDrugbanksmall molecule
DB15822 PralsetinibDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
JAK1_HUMANLMO4_MOUSEBioGRID15677447 details
JAK1_HUMANIL6RB_MOUSEBioGRID15677447 details