Entity Details

Primary name CXCR2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP25025
EntryNameCXCR2_HUMAN
FullNameC-X-C chemokine receptor type 2
TaxID9606
Evidenceevidence at protein level
Length360
SequenceStatuscomplete
DateCreated1992-05-01
DateModified2021-06-02

Ontological Relatives

GenesCXCR2

GO terms

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GOName
GO:0002407 dendritic cell chemotaxis
GO:0004918 interleukin-8 receptor activity
GO:0004930 G protein-coupled receptor activity
GO:0005654 nucleoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0006968 cellular defense response
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0008284 positive regulation of cell population proliferation
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0015630 microtubule cytoskeleton
GO:0016020 membrane
GO:0016493 C-C chemokine receptor activity
GO:0016494 C-X-C chemokine receptor activity
GO:0019722 calcium-mediated signaling
GO:0019957 C-C chemokine binding
GO:0019959 interleukin-8 binding
GO:0030593 neutrophil chemotaxis
GO:0030667 secretory granule membrane
GO:0031623 receptor internalization
GO:0038112 interleukin-8-mediated signaling pathway
GO:0042119 neutrophil activation
GO:0042629 mast cell granule
GO:0043312 neutrophil degranulation
GO:0060326 cell chemotaxis
GO:0072686 mitotic spindle

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000057 CXC chemokine receptor 2FamilyFamily
IPR000174 CXC chemokine receptor 1/2FamilyFamily
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
CXCR2_HUMANHG2A_MOUSEIntAct17435771 details