Entity Details

Primary name ARBK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP25098
EntryNameARBK1_HUMAN
FullNameBeta-adrenergic receptor kinase 1
TaxID9606
Evidenceevidence at protein level
Length689
SequenceStatuscomplete
DateCreated1992-05-01
DateModified2021-06-02

Ontological Relatives

GenesGRK2

GO terms

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GOName
GO:0002029 desensitization of G protein-coupled receptor signaling pathway
GO:0003108 negative regulation of the force of heart contraction by chemical signal
GO:0004672 protein kinase activity
GO:0004703 G protein-coupled receptor kinase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005929 cilium
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007213 G protein-coupled acetylcholine receptor signaling pathway
GO:0007217 tachykinin receptor signaling pathway
GO:0007507 heart development
GO:0016020 membrane
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019079 viral genome replication
GO:0031623 receptor internalization
GO:0031694 alpha-2A adrenergic receptor binding
GO:0031755 Edg-2 lysophosphatidic acid receptor binding
GO:0033605 positive regulation of catecholamine secretion
GO:0045202 synapse
GO:0045988 negative regulation of striated muscle contraction
GO:0046718 viral entry into host cell
GO:0047696 beta-adrenergic receptor kinase activity
GO:0060048 cardiac muscle contraction
GO:1901081 negative regulation of relaxation of smooth muscle

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR000239 GPCR kinaseFamilyFamily
IPR000719 Protein kinase domainDomainDomain
IPR000961 AGC-kinase, C-terminalDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR016137 RGS domainDomainDomain
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR036305 RGS domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00171 ATPDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
ARBK1_HUMANRPGF3_MOUSEBioGRID20861385 details