Entity Details

Primary name ATPA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP25705
EntryNameATPA_HUMAN
FullNameATP synthase subunit alpha, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length553
SequenceStatuscomplete
DateCreated1992-05-01
DateModified2021-06-02

Ontological Relatives

GenesATP5F1A

GO terms

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GOName
GO:0001937 negative regulation of endothelial cell proliferation
GO:0003723 RNA binding
GO:0005524 ATP binding
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005753 mitochondrial proton-transporting ATP synthase complex
GO:0005759 mitochondrial matrix
GO:0005886 plasma membrane
GO:0006629 lipid metabolic process
GO:0006754 ATP biosynthetic process
GO:0015986 ATP synthesis coupled proton transport
GO:0016020 membrane
GO:0042288 MHC class I protein binding
GO:0042407 cristae formation
GO:0042776 mitochondrial ATP synthesis coupled proton transport
GO:0043531 ADP binding
GO:0043532 angiostatin binding
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0045259 proton-transporting ATP synthase complex
GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)
GO:0046933 proton-transporting ATP synthase activity, rotational mechanism
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Cell membrane
Mitochondrion
Mitochondrion inner membrane

Domains

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DomainNameCategoryType
IPR000194 ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domainDomainDomain
IPR000793 ATP synthase, alpha subunit, C-terminalDomainDomain
IPR004100 ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domainDomainDomain
IPR005294 ATP synthase, F1 complex, alpha subunitFamilyFamily
IPR020003 ATPase, alpha/beta subunit, nucleotide-binding domain, active siteSiteActive site
IPR023366 ATP synthase subunit alpha, N-terminal domain-like superfamilyFamilyHomologous superfamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR033732 ATP synthase, F1 complex, alpha subunit nucleotide-binding domainDomainDomain
IPR036121 ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamilyFamilyHomologous superfamily
IPR038376 ATP synthase, alpha subunit, C-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB04216 QuercetinDrugbanksmall molecule
DB07384 1-ACETYL-2-CARBOXYPIPERIDINEDrugbanksmall molecule
DB07394 AUROVERTIN BDrugbanksmall molecule
DB08399 PiceatannolDrugbanksmall molecule
DB08629 N1-(2-AMINO-4-METHYLPENTYL)OCTAHYDRO-PYRROLO[1,2-A] PYRIMIDINEDrugbanksmall molecule
DB11638 ArtenimolDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
ATPA_HUMANYAP1_MOUSEBioGRID30865227 details
ATPA_HUMANMK13_MOUSEBioGRID19135240 details