Entity Details

Primary name TNR5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP25942
EntryNameTNR5_HUMAN
FullNameTumor necrosis factor receptor superfamily member 5
TaxID9606
Evidenceevidence at protein level
Length277
SequenceStatuscomplete
DateCreated1992-05-01
DateModified2021-06-02

Ontological Relatives

GenesCD40

GO terms

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GOName
GO:0001934 positive regulation of protein phosphorylation
GO:0002768 immune response-regulating cell surface receptor signaling pathway
GO:0003823 antigen binding
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006874 cellular calcium ion homeostasis
GO:0006954 inflammatory response
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0019724 B cell mediated immunity
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0023035 CD40 signaling pathway
GO:0030168 platelet activation
GO:0030890 positive regulation of B cell proliferation
GO:0031625 ubiquitin protein ligase binding
GO:0032735 positive regulation of interleukin-12 production
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0033590 response to cobalamin
GO:0034341 response to interferon-gamma
GO:0035631 CD40 receptor complex
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0036018 cellular response to erythropoietin
GO:0038023 signaling receptor activity
GO:0042100 B cell proliferation
GO:0042113 B cell activation
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042832 defense response to protozoan
GO:0043025 neuronal cell body
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043196 varicosity
GO:0043231 intracellular membrane-bounded organelle
GO:0043406 positive regulation of MAP kinase activity
GO:0043491 protein kinase B signaling
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0043547 positive regulation of GTPase activity
GO:0045766 positive regulation of angiogenesis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048304 positive regulation of isotype switching to IgG isotypes
GO:0050776 regulation of immune response
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051607 defense response to virus
GO:0065003 protein-containing complex assembly
GO:0070062 extracellular exosome
GO:0071222 cellular response to lipopolysaccharide
GO:0071260 cellular response to mechanical stimulus
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0090037 positive regulation of protein kinase C signaling
GO:1901652 response to peptide
GO:2000353 positive regulation of endothelial cell apoptotic process

Subcellular Location

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Subcellular Location
Cell membrane
Secreted

Domains

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DomainNameCategoryType
IPR001368 TNFR/NGFR cysteine-rich regionDomainDomain
IPR020435 Tumour necrosis factor receptor 5FamilyFamily
IPR034021 Tumour necrosis factor receptor 5, N-terminalDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB06360 LucatumumabDrugbankbiotech
DB12589 DacetuzumabDrugbankbiotech

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
TNR5_HUMANOTU7B_MOUSEBioGRID, DIP23334419 details