Entity Details

Primary name IKBA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP25963
EntryNameIKBA_HUMAN
FullNameNF-kappa-B inhibitor alpha
TaxID9606
Evidenceevidence at protein level
Length317
SequenceStatuscomplete
DateCreated1992-05-01
DateModified2021-06-02

Ontological Relatives

GenesNFKBIA

GO terms

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GOName
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006606 protein import into nucleus
GO:0006915 apoptotic process
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007253 cytoplasmic sequestering of NF-kappaB
GO:0008134 transcription factor binding
GO:0008139 nuclear localization sequence binding
GO:0010745 negative regulation of macrophage derived foam cell differentiation
GO:0010875 positive regulation of cholesterol efflux
GO:0010888 negative regulation of lipid storage
GO:0016032 viral process
GO:0016579 protein deubiquitination
GO:0019899 enzyme binding
GO:0031625 ubiquitin protein ligase binding
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032270 positive regulation of cellular protein metabolic process
GO:0032495 response to muramyl dipeptide
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0033256 I-kappaB/NF-kappaB complex
GO:0034142 toll-like receptor 4 signaling pathway
GO:0035994 response to muscle stretch
GO:0042127 regulation of cell population proliferation
GO:0042802 identical protein binding
GO:0042994 cytoplasmic sequestering of transcription factor
GO:0043066 negative regulation of apoptotic process
GO:0043330 response to exogenous dsRNA
GO:0043392 negative regulation of DNA binding
GO:0045638 negative regulation of myeloid cell differentiation
GO:0045746 negative regulation of Notch signaling pathway
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050729 positive regulation of inflammatory response
GO:0051059 NF-kappaB binding
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0070417 cellular response to cold
GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0070498 interleukin-1-mediated signaling pathway
GO:1901222 regulation of NIK/NF-kappaB signaling

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR002110 Ankyrin repeatRepeatRepeat
IPR020683 Ankyrin repeat-containing domainDomainDomain
IPR036770 Ankyrin repeat-containing domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00945 Acetylsalicylic acidDrugbanksmall molecule
DB05983 Bardoxolone methylDrugbanksmall molecule
DB06543 AstaxanthinDrugbanksmall molecule

Interactions

3 interactions