Entity Details

Primary name PAX6_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP26367
EntryNamePAX6_HUMAN
FullNamePaired box protein Pax-6
TaxID9606
Evidenceevidence at protein level
Length422
SequenceStatuscomplete
DateCreated1992-08-01
DateModified2021-06-02

Ontological Relatives

GenesPAX6

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001568 blood vessel development
GO:0001654 eye development
GO:0003322 pancreatic A cell development
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007417 central nervous system development
GO:0007601 visual perception
GO:0008134 transcription factor binding
GO:0009611 response to wounding
GO:0009887 animal organ morphogenesis
GO:0010628 positive regulation of gene expression
GO:0019901 protein kinase binding
GO:0021517 ventral spinal cord development
GO:0035035 histone acetyltransferase binding
GO:0042593 glucose homeostasis
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048663 neuron fate commitment
GO:0048856 anatomical structure development
GO:0050768 negative regulation of neurogenesis
GO:0061072 iris morphogenesis
GO:0061303 cornea development in camera-type eye
GO:0070412 R-SMAD binding
GO:1904798 positive regulation of core promoter binding
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001356 Homeobox domainDomainDomain
IPR001523 Paired domainDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR017970 Homeobox, conserved siteSiteConserved site
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR043182 Paired DNA-binding domainDomainDomain
IPR043565 PAX familyFamilyFamily

Diseases

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Interactions

4 interactions