Entity Details

Primary name PTBP1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP26599
EntryNamePTBP1_HUMAN
FullNamePolypyrimidine tract-binding protein 1
TaxID9606
Evidenceevidence at protein level
Length531
SequenceStatuscomplete
DateCreated1992-08-01
DateModified2021-06-02

Ontological Relatives

GenesPTBP1

GO terms

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GOName
GO:0000381 regulation of alternative mRNA splicing, via spliceosome
GO:0000398 mRNA splicing, via spliceosome
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0006397 mRNA processing
GO:0008187 poly-pyrimidine tract binding
GO:0008380 RNA splicing
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0016020 membrane
GO:0016070 RNA metabolic process
GO:0033119 negative regulation of RNA splicing
GO:0035307 positive regulation of protein dephosphorylation
GO:0036002 pre-mRNA binding
GO:0043484 regulation of RNA splicing
GO:0045595 regulation of cell differentiation
GO:0048025 negative regulation of mRNA splicing, via spliceosome
GO:0051148 negative regulation of muscle cell differentiation
GO:0070062 extracellular exosome
GO:0070886 positive regulation of calcineurin-NFAT signaling cascade
GO:0075522 IRES-dependent viral translational initiation

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000504 RNA recognition motif domainDomainDomain
IPR006536 HnRNP-L/PTBFamilyFamily
IPR012677 Nucleotide-binding alpha-beta plait domain superfamilyFamilyHomologous superfamily
IPR021790 PTBP1, RNA recognition motif 2-likeDomainDomain
IPR034798 Polypyrimidine tract-binding protein1/2/3, RNA recognition motif 2DomainDomain
IPR035000 PTBP1, RNA recognition motif 1DomainDomain
IPR035001 PTBP1, RNA recognition motif 3DomainDomain
IPR035979 RNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
PTBP1_HUMANRAVR2_MOUSEMINT16051233 details
PTBP1_HUMANRAVR1_MOUSEBioGRID11724819 details