Entity Details

Primary name AVR2A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP27037
EntryNameAVR2A_HUMAN
FullNameActivin receptor type-2A
TaxID9606
Evidenceevidence at protein level
Length513
SequenceStatuscomplete
DateCreated1992-08-01
DateModified2021-06-02

Ontological Relatives

GenesACVR2A

GO terms

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GOName
GO:0001702 gastrulation with mouth forming second
GO:0001934 positive regulation of protein phosphorylation
GO:0004674 protein serine/threonine kinase activity
GO:0004675 transmembrane receptor protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006468 protein phosphorylation
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007283 spermatogenesis
GO:0007368 determination of left/right symmetry
GO:0007498 mesoderm development
GO:0009952 anterior/posterior pattern specification
GO:0009986 cell surface
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0015026 coreceptor activity
GO:0019838 growth factor binding
GO:0030165 PDZ domain binding
GO:0030501 positive regulation of bone mineralization
GO:0030509 BMP signaling pathway
GO:0030513 positive regulation of BMP signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0032924 activin receptor signaling pathway
GO:0032927 positive regulation of activin receptor signaling pathway
GO:0034673 inhibin-betaglycan-ActRII complex
GO:0034711 inhibin binding
GO:0042713 sperm ejaculation
GO:0043084 penile erection
GO:0043235 receptor complex
GO:0043621 protein self-association
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0048179 activin receptor complex
GO:0048185 activin binding
GO:0048706 embryonic skeletal system development
GO:0050999 regulation of nitric-oxide synthase activity
GO:0060011 Sertoli cell proliferation
GO:0071363 cellular response to growth factor stimulus
GO:0071773 cellular response to BMP stimulus
GO:0098821 BMP receptor activity

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR000333 Ser/Thr protein kinase, TGFB receptorFamilyFamily
IPR000472 Activin types I and II receptor domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB12118 SotaterceptDrugbankbiotech

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
AVR2A_HUMANMAGI2_MOUSEMINT10681527 details
AVR2A_HUMANDOK1_MOUSEBioGRID11927552 details