Entity Details

Primary name RFA1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP27694
EntryNameRFA1_HUMAN
FullNameReplication protein A 70 kDa DNA-binding subunit
TaxID9606
Evidenceevidence at protein level
Length616
SequenceStatuscomplete
DateCreated1992-08-01
DateModified2021-06-02

Ontological Relatives

GenesRPA1

GO terms

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GOName
GO:0003684 damaged DNA binding
GO:0003697 single-stranded DNA binding
GO:0005654 nucleoplasm
GO:0005662 DNA replication factor A complex
GO:0006260 DNA replication
GO:0006284 base-excision repair
GO:0006297 nucleotide-excision repair, DNA gap filling
GO:0007004 telomere maintenance via telomerase
GO:0000723 telomere maintenance
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0006261 DNA-dependent DNA replication
GO:0006270 DNA replication initiation
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006287 base-excision repair, gap-filling
GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion
GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006298 mismatch repair
GO:0006974 cellular response to DNA damage stimulus
GO:0019985 translesion synthesis
GO:0032201 telomere maintenance via semi-conservative replication
GO:0033683 nucleotide-excision repair, DNA incision
GO:0034502 protein localization to chromosome
GO:0042276 error-prone translesion synthesis
GO:0051321 meiotic cell cycle
GO:0070987 error-free translesion synthesis
GO:0098505 G-rich strand telomeric DNA binding
GO:1900034 regulation of cellular response to heat
GO:1901796 regulation of signal transduction by p53 class mediator
GO:0006268 DNA unwinding involved in DNA replication
GO:0036297 interstrand cross-link repair
GO:0042769 DNA damage response, detection of DNA damage
GO:0046872 metal ion binding
GO:0000724 double-strand break repair via homologous recombination
GO:0006281 DNA repair
GO:0006289 nucleotide-excision repair
GO:0006293 nucleotide-excision repair, preincision complex stabilization
GO:0006294 nucleotide-excision repair, preincision complex assembly
GO:0006310 DNA recombination
GO:0016605 PML body
GO:0043047 single-stranded telomeric DNA binding
GO:0090734 site of DNA damage

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR004365 OB-fold nucleic acid binding domain, AA-tRNA synthetase-typeDomainDomain
IPR004591 Replication factor A protein 1FamilyFamily
IPR007199 Replication factor-A protein 1, N-terminalDomainDomain
IPR012340 Nucleic acid-binding, OB-foldFamilyHomologous superfamily
IPR013955 Replication factor A, C-terminalDomainDomain
IPR031657 Replication protein A, OB domainDomainDomain

Diseases

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Interactions

0 interactions

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