Entity Details

Primary name APEX1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP27695
EntryNameAPEX1_HUMAN
FullNameDNA-(apurinic or apyrimidinic site) endonuclease
TaxID9606
Evidenceevidence at protein level
Length318
SequenceStatuscomplete
DateCreated1992-08-01
DateModified2021-06-02

Ontological Relatives

GenesAPEX1

GO terms

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GOName
GO:0000723 telomere maintenance
GO:0000781 chromosome, telomeric region
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0003691 double-stranded telomeric DNA binding
GO:0003713 transcription coactivator activity
GO:0003714 transcription corepressor activity
GO:0003723 RNA binding
GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0004519 endonuclease activity
GO:0004520 endodeoxyribonuclease activity
GO:0004523 RNA-DNA hybrid ribonuclease activity
GO:0004528 phosphodiesterase I activity
GO:0004844 uracil DNA N-glycosylase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005813 centrosome
GO:0005840 ribosome
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006286 base-excision repair, base-free sugar-phosphate removal
GO:0006287 base-excision repair, gap-filling
GO:0006310 DNA recombination
GO:0007568 aging
GO:0008081 phosphoric diester hydrolase activity
GO:0008309 double-stranded DNA exodeoxyribonuclease activity
GO:0008311 double-stranded DNA 3'-5' exodeoxyribonuclease activity
GO:0008408 3'-5' exonuclease activity
GO:0014912 negative regulation of smooth muscle cell migration
GO:0016491 oxidoreductase activity
GO:0016607 nuclear speck
GO:0016890 site-specific endodeoxyribonuclease activity, specific for altered base
GO:0031490 chromatin DNA binding
GO:0042493 response to drug
GO:0042981 regulation of apoptotic process
GO:0043488 regulation of mRNA stability
GO:0044877 protein-containing complex binding
GO:0045454 cell redox homeostasis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0048471 perinuclear region of cytoplasm
GO:0051059 NF-kappaB binding
GO:0070301 cellular response to hydrogen peroxide
GO:0071320 cellular response to cAMP
GO:0071375 cellular response to peptide hormone stimulus
GO:0080111 DNA demethylation
GO:0097698 telomere maintenance via base-excision repair
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle

Subcellular Location

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Subcellular Location
Cytoplasm
Endoplasmic reticulum
Mitochondrion
Nucleus
Nucleus speckle

Domains

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DomainNameCategoryType
IPR004808 AP endonuclease 1FamilyFamily
IPR005135 Endonuclease/exonuclease/phosphataseDomainDomain
IPR020847 AP endonuclease 1, binding siteSiteBinding site
IPR020848 AP endonuclease 1, conserved siteSiteConserved site
IPR036691 Endonuclease/exonuclease/phosphatase superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB04967 LucanthoneDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
APEX1_HUMANHLF_MOUSEBioGRID10671489 details
APEX1_HUMANSIR6_MOUSEBioGRID26063178 details