Entity Details

Primary name CALR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP27797
EntryNameCALR_HUMAN
FullNameCalreticulin
TaxID9606
Evidenceevidence at protein level
Length417
SequenceStatuscomplete
DateCreated1992-08-01
DateModified2021-06-02

Ontological Relatives

GenesCALR

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001669 acrosomal vesicle
GO:0001849 complement component C1q complex binding
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002502 peptide antigen assembly with MHC class I protein complex
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005178 integrin binding
GO:0005506 iron ion binding
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0005789 endoplasmic reticulum membrane
GO:0005790 smooth endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005844 polysome
GO:0005925 focal adhesion
GO:0006355 regulation of transcription, DNA-templated
GO:0006457 protein folding
GO:0006611 protein export from nucleus
GO:0006874 cellular calcium ion homeostasis
GO:0006898 receptor-mediated endocytosis
GO:0007283 spermatogenesis
GO:0008270 zinc ion binding
GO:0008284 positive regulation of cell population proliferation
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0010595 positive regulation of endothelial cell migration
GO:0010628 positive regulation of gene expression
GO:0016020 membrane
GO:0017148 negative regulation of translation
GO:0022417 protein maturation by protein folding
GO:0030133 transport vesicle
GO:0030246 carbohydrate binding
GO:0030670 phagocytic vesicle membrane
GO:0030866 cortical actin cytoskeleton organization
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0031625 ubiquitin protein ligase binding
GO:0032355 response to estradiol
GO:0033018 sarcoplasmic reticulum lumen
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway
GO:0033574 response to testosterone
GO:0034504 protein localization to nucleus
GO:0034975 protein folding in endoplasmic reticulum
GO:0036500 ATF6-mediated unfolded protein response
GO:0040020 regulation of meiotic nuclear division
GO:0042277 peptide binding
GO:0042493 response to drug
GO:0042562 hormone binding
GO:0042824 MHC class I peptide loading complex
GO:0042921 glucocorticoid receptor signaling pathway
GO:0042981 regulation of apoptotic process
GO:0044183 protein folding chaperone
GO:0044322 endoplasmic reticulum quality control compartment
GO:0045665 negative regulation of neuron differentiation
GO:0045787 positive regulation of cell cycle
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048387 negative regulation of retinoic acid receptor signaling pathway
GO:0048471 perinuclear region of cytoplasm
GO:0050681 androgen receptor binding
GO:0050766 positive regulation of phagocytosis
GO:0050821 protein stabilization
GO:0051082 unfolded protein binding
GO:0051087 chaperone binding
GO:0051208 sequestering of calcium ion
GO:0055007 cardiac muscle cell differentiation
GO:0060473 cortical granule
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0071285 cellular response to lithium ion
GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane
GO:0071682 endocytic vesicle lumen
GO:0090398 cellular senescence
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
GO:1901164 negative regulation of trophoblast cell migration
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1990668 vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane
GO:2000510 positive regulation of dendritic cell chemotaxis

Subcellular Location

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Subcellular Location
Cell surface
Cytolytic granule
Cytoplasm
Cytoplasmic vesicle
Endoplasmic reticulum lumen
Sarcoplasmic reticulum lumen
Secreted

Domains

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DomainNameCategoryType
IPR001580 Calreticulin/calnexinFamilyFamily
IPR009033 Calreticulin/calnexin, P domain superfamilyFamilyHomologous superfamily
IPR009169 CalreticulinFamilyFamily
IPR013320 Concanavalin A-like lectin/glucanase domain superfamilyFamilyHomologous superfamily
IPR018124 Calreticulin/calnexin, conserved siteSiteConserved site

Diseases

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Drugs

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DrugNameSourceType
DB00025 Antihemophilic factor, human recombinantDrugbankbiotech
DB00031 TenecteplaseDrugbankbiotech
DB01065 MelatoninDrugbanksmall molecule
DB06245 LanoteplaseDrugbankbiotech
DB09130 CopperDrugbanksmall molecule
DB11093 Calcium citrateDrugbanksmall molecule
DB11348 Calcium PhosphateDrugbanksmall molecule
DB13949 Ferric cationDrugbanksmall molecule
DB13998 Lonoctocog alfaDrugbankbiotech
DB13999 Moroctocog alfaDrugbankbiotech
DB14481 Calcium phosphate dihydrateDrugbanksmall molecule
DB14520 Tetraferric tricitrate decahydrateDrugbanksmall molecule

Interactions

0 interactions

InteractorPartnerSourcesPublicationsLink