Entity Details

Primary name PDE4A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP27815
EntryNamePDE4A_HUMAN
FullNamecAMP-specific 3',5'-cyclic phosphodiesterase 4A
TaxID9606
Evidenceevidence at protein level
Length886
SequenceStatuscomplete
DateCreated1992-08-01
DateModified2021-06-02

Ontological Relatives

GenesPDE4A

GO terms

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GOName
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006198 cAMP catabolic process
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007608 sensory perception of smell
GO:0010738 regulation of protein kinase A signaling
GO:0016020 membrane
GO:0030552 cAMP binding
GO:0032587 ruffle membrane
GO:0035690 cellular response to drug
GO:0043949 regulation of cAMP-mediated signaling
GO:0046872 metal ion binding
GO:0048471 perinuclear region of cytoplasm

Subcellular Location

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Subcellular Location
Cell projection
Cytoplasm
Membrane

Domains

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DomainNameCategoryType
IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domainDomainDomain
IPR003607 HD/PDEase domainDomainDomain
IPR023088 3'5'-cyclic nucleotide phosphodiesteraseFamilyFamily
IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved siteSiteConserved site
IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamilyFamilyHomologous superfamily
IPR040844 Phosphodiesterase 4 upstream conserved regions (UCR)DomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00201 CaffeineDrugbanksmall molecule
DB00277 TheophyllineDrugbanksmall molecule
DB00651 DyphyllineDrugbanksmall molecule
DB00824 EnprofyllineDrugbanksmall molecule
DB00975 DipyridamoleDrugbanksmall molecule
DB01088 IloprostDrugbanksmall molecule
DB01303 OxtriphyllineDrugbanksmall molecule
DB01427 AmrinoneDrugbanksmall molecule
DB01656 RoflumilastDrugbanksmall molecule
DB01791 PiclamilastDrugbanksmall molecule
DB05219 CrisaboroleDrugbanksmall molecule
DB05266 IbudilastDrugbanksmall molecule
DB06479 PropentofyllineDrugbanksmall molecule
DB06751 DrotaverineDrugbanksmall molecule
DB06842 (4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-oneDrugbanksmall molecule
DB08299 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acidDrugbanksmall molecule
DB08811 TofisopamDrugbanksmall molecule
DB09283 TrapidilDrugbanksmall molecule

Interactions

0 interactions

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