Entity Details

Primary name P85A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP27986
EntryNameP85A_HUMAN
FullNamePhosphatidylinositol 3-kinase regulatory subunit alpha
TaxID9606
Evidenceevidence at protein level
Length724
SequenceStatuscomplete
DateCreated1992-08-01
DateModified2021-06-02

Ontological Relatives

GenesPIK3R1

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001678 cellular glucose homeostasis
GO:0001784 phosphotyrosine residue binding
GO:0001953 negative regulation of cell-matrix adhesion
GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005158 insulin receptor binding
GO:0005159 insulin-like growth factor receptor binding
GO:0005168 neurotrophin TRKA receptor binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005801 cis-Golgi network
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005942 phosphatidylinositol 3-kinase complex
GO:0005943 phosphatidylinositol 3-kinase complex, class IA
GO:0006468 protein phosphorylation
GO:0006606 protein import into nucleus
GO:0006661 phosphatidylinositol biosynthetic process
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007411 axon guidance
GO:0008134 transcription factor binding
GO:0008286 insulin receptor signaling pathway
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010592 positive regulation of lamellipodium assembly
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016020 membrane
GO:0016032 viral process
GO:0019221 cytokine-mediated signaling pathway
GO:0019903 protein phosphatase binding
GO:0030168 platelet activation
GO:0030183 B cell differentiation
GO:0030335 positive regulation of cell migration
GO:0031295 T cell costimulation
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032869 cellular response to insulin stimulus
GO:0033120 positive regulation of RNA splicing
GO:0034446 substrate adhesion-dependent cell spreading
GO:0034644 cellular response to UV
GO:0034976 response to endoplasmic reticulum stress
GO:0035014 phosphatidylinositol 3-kinase regulator activity
GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0038128 ERBB2 signaling pathway
GO:0042307 positive regulation of protein import into nucleus
GO:0043066 negative regulation of apoptotic process
GO:0043125 ErbB-3 class receptor binding
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0043551 regulation of phosphatidylinositol 3-kinase activity
GO:0043559 insulin binding
GO:0043560 insulin receptor substrate binding
GO:0045671 negative regulation of osteoclast differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046326 positive regulation of glucose import
GO:0046626 regulation of insulin receptor signaling pathway
GO:0046854 phosphatidylinositol phosphate biosynthetic process
GO:0046935 1-phosphatidylinositol-3-kinase regulator activity
GO:0046982 protein heterodimerization activity
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048471 perinuclear region of cytoplasm
GO:0050821 protein stabilization
GO:0050852 T cell receptor signaling pathway
GO:0050900 leukocyte migration
GO:0051491 positive regulation of filopodium assembly
GO:0051497 negative regulation of stress fiber assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0060396 growth hormone receptor signaling pathway
GO:0120183 positive regulation of focal adhesion disassembly
GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response
GO:1903078 positive regulation of protein localization to plasma membrane
GO:1990578 perinuclear endoplasmic reticulum membrane

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000198 Rho GTPase-activating protein domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR008936 Rho GTPase activation proteinFamilyHomologous superfamily
IPR032498 PI3K regulatory subunit p85-related , inter-SH2 domainDomainDomain
IPR035020 PI3K p85 subunit, C-terminal SH2 domainDomainDomain
IPR035022 PI3K p85 subunit, N-terminal SH2 domainDomainDomain
IPR035591 Phosphatidylinositol 3-kinase regulatory subunit alpha, SH3 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily
IPR044124 PIK3R1, inter-SH2 domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB01064 IsoprenalineDrugbanksmall molecule
DB05210 SF1126Drugbanksmall molecule
DB06486 EnzastaurinDrugbanksmall molecule
DB08059 WortmanninDrugbanksmall molecule