Entity Details

Primary name KGP1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP0C605
EntryNameKGP1_MOUSE
FullNamecGMP-dependent protein kinase 1
TaxID10090
Evidenceevidence at protein level
Length671
SequenceStatuscomplete
DateCreated2008-01-15
DateModified2021-06-02

Ontological Relatives

GenesPrkg1

GO terms

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GOName
GO:0001669 acrosomal vesicle
GO:0001764 neuron migration
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004692 cGMP-dependent protein kinase activity
GO:0005246 calcium channel regulator activity
GO:0005524 ATP binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0010920 negative regulation of inositol phosphate biosynthetic process
GO:0014050 negative regulation of glutamate secretion
GO:0014912 negative regulation of smooth muscle cell migration
GO:0016020 membrane
GO:0016358 dendrite development
GO:0019934 cGMP-mediated signaling
GO:0030553 cGMP binding
GO:0030900 forebrain development
GO:0042753 positive regulation of circadian rhythm
GO:0042802 identical protein binding
GO:0043087 regulation of GTPase activity
GO:0045822 negative regulation of heart contraction
GO:0045986 negative regulation of smooth muscle contraction
GO:0048273 mitogen-activated protein kinase p38 binding
GO:0060087 relaxation of vascular associated smooth muscle
GO:0061049 cell growth involved in cardiac muscle cell development
GO:0090331 negative regulation of platelet aggregation
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1902608 positive regulation of large conductance calcium-activated potassium channel activity
GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation
GO:1904753 negative regulation of vascular associated smooth muscle cell migration
GO:2000224 regulation of testosterone biosynthetic process

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000595 Cyclic nucleotide-binding domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR000961 AGC-kinase, C-terminalDomainDomain
IPR002374 cGMP-dependent kinaseFamilyFamily
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR014710 RmlC-like jelly roll foldFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR018488 Cyclic nucleotide-binding, conserved siteSiteConserved site
IPR018490 Cyclic nucleotide-binding-likeFamilyHomologous superfamily
IPR031831 cGMP-dependent protein kinase, N-terminal coiled-coil domainDomainDomain
IPR035014 cGMP-dependent protein kinase, catalytic domainDomainDomain

Diseases

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