Entity Details

Primary name MK01_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP28482
EntryNameMK01_HUMAN
FullNameMitogen-activated protein kinase 1
TaxID9606
Evidenceevidence at protein level
Length360
SequenceStatuscomplete
DateCreated1992-12-01
DateModified2021-06-02

Ontological Relatives

GenesMAPK1

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000186 obsolete activation of MAPKK activity
GO:0001784 phosphotyrosine residue binding
GO:0004674 protein serine/threonine kinase activity
GO:0005770 late endosome
GO:0005788 endoplasmic reticulum lumen
GO:0005829 cytosol
GO:0006915 apoptotic process
GO:0006935 chemotaxis
GO:0007411 axon guidance
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0010628 positive regulation of gene expression
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling
GO:0016032 viral process
GO:0019233 sensory perception of pain
GO:0030168 platelet activation
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032212 positive regulation of telomere maintenance via telomerase
GO:0032991 protein-containing complex
GO:0042802 identical protein binding
GO:0043627 response to estrogen
GO:0045893 positive regulation of transcription, DNA-templated
GO:0051090 regulation of DNA-binding transcription factor activity
GO:0070371 ERK1 and ERK2 cascade
GO:0072584 caveolin-mediated endocytosis
GO:0106311 protein threonine kinase activity
GO:0000187 obsolete activation of MAPK activity
GO:0003690 double-stranded DNA binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0005856 cytoskeleton
GO:0005925 focal adhesion
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007268 chemical synaptic transmission
GO:0007568 aging
GO:0007611 learning or memory
GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity
GO:0009636 response to toxic substance
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0015966 diadenosine tetraphosphate biosynthetic process
GO:0018105 peptidyl-serine phosphorylation
GO:0019902 phosphatase binding
GO:0031143 pseudopodium
GO:0031435 mitogen-activated protein kinase kinase kinase binding
GO:0035578 azurophil granule lumen
GO:0038127 ERBB signaling pathway
GO:0042307 positive regulation of protein import into nucleus
GO:0042473 outer ear morphogenesis
GO:0045596 negative regulation of cell differentiation
GO:0046697 decidualization
GO:0050853 B cell receptor signaling pathway
GO:0051403 stress-activated MAPK cascade
GO:0051493 regulation of cytoskeleton organization
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060291 long-term synaptic potentiation
GO:0060440 trachea formation
GO:0060716 labyrinthine layer blood vessel development
GO:0071276 cellular response to cadmium ion
GO:0072686 mitotic spindle
GO:0090170 regulation of Golgi inheritance
GO:0120041 positive regulation of macrophage proliferation
GO:2000641 regulation of early endosome to late endosome transport
GO:0004708 MAP kinase kinase activity
GO:0005524 ATP binding
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0007166 cell surface receptor signaling pathway
GO:0008134 transcription factor binding
GO:0010759 positive regulation of macrophage chemotaxis
GO:0014069 postsynaptic density
GO:0019858 cytosine metabolic process
GO:0030424 axon
GO:0032839 dendrite cytoplasm
GO:0034198 cellular response to amino acid starvation
GO:0034614 cellular response to reactive oxygen species
GO:0035556 intracellular signal transduction
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043312 neutrophil degranulation
GO:0050852 T cell receptor signaling pathway
GO:0060324 face development
GO:0061308 cardiac neural crest cell development involved in heart development
GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus
GO:0106310 protein serine kinase activity
GO:1903351 cellular response to dopamine
GO:1904813 ficolin-1-rich granule lumen
GO:0004707 MAP kinase activity
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005769 early endosome
GO:0005794 Golgi apparatus
GO:0006974 cellular response to DNA damage stimulus
GO:0007049 cell cycle
GO:0018107 peptidyl-threonine phosphorylation
GO:0030278 regulation of ossification
GO:0030641 regulation of cellular pH
GO:0030878 thyroid gland development
GO:0031647 regulation of protein stability
GO:0032872 regulation of stress-activated MAPK cascade
GO:0033598 mammary gland epithelial cell proliferation
GO:0033668 negative regulation by symbiont of host apoptotic process
GO:0035094 response to nicotine
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0043204 perikaryon
GO:0043330 response to exogenous dsRNA
GO:0045727 positive regulation of translation
GO:0048538 thymus development
GO:0051973 positive regulation of telomerase activity
GO:0060020 Bergmann glial cell differentiation
GO:0060425 lung morphogenesis
GO:0070849 response to epidermal growth factor
GO:0071356 cellular response to tumor necrosis factor
GO:1900034 regulation of cellular response to heat
GO:1904355 positive regulation of telomere capping

Subcellular Location

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Subcellular Location
Membrane
Nucleus
Cell junction
Cytoplasm

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR003527 Mitogen-activated protein (MAP) kinase, conserved siteSiteConserved site
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR008349 Mitogen-activated protein (MAP) kinase, ERK1/2FamilyFamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

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Drugs

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DrugNameSourceType
DB00945 Acetylsalicylic acidDrugbanksmall molecule
DB01017 MinocyclineDrugbanksmall molecule
DB01064 IsoprenalineDrugbanksmall molecule
DB01169 Arsenic trioxideDrugbanksmall molecule
DB02116 OlomoucineDrugbanksmall molecule
DB02482 PhosphonothreonineDrugbanksmall molecule
DB02733 PurvalanolDrugbanksmall molecule
DB04338 SB220025Drugbanksmall molecule
DB06195 SeliciclibDrugbanksmall molecule
DB06641 PerifosineDrugbanksmall molecule
DB06877 N,N-DIMETHYL-4-(4-PHENYL-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDEDrugbanksmall molecule
DB07010 N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDEDrugbanksmall molecule
DB07264 (S)-N-(1-(3-CHLORO-4-FLUOROPHENYL)-2-HYDROXYETHYL)-4-(4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDEDrugbanksmall molecule
DB07788 (3R,5Z,8S,9S,11E)-8,9,16-TRIHYDROXY-14-METHOXY-3-METHYL-3,4,9,10-TETRAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,7(8H)-DIONEDrugbanksmall molecule
DB07794 5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINEDrugbanksmall molecule
DB07905 (1aR,8S,13S,14S,15aR)-5,13,14-trihydroxy-3-methoxy-8-methyl-8,9,13,14,15,15a-hexahydro-6H-oxireno[k][2]benzoxacyclotetradecine-6,12(1aH)-dioneDrugbanksmall molecule
DB08513 [4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACIDDrugbanksmall molecule
DB08521 4-[4-(4-Fluorophenyl)-2-[4-[(R)-methylsulfinyl]phenyl]-1H-imidazol-5-yl]pyridineDrugbanksmall molecule
DB11120 TurpentineDrugbanksmall molecule
DB13930 UlixertinibDrugbanksmall molecule