Entity Details

Primary name GRN_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP28799
EntryNameGRN_HUMAN
FullNameProgranulin
TaxID9606
Evidenceevidence at protein level
Length593
SequenceStatuscomplete
DateCreated1992-12-01
DateModified2021-06-02

Ontological Relatives

GenesGRN

GO terms

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GOName
GO:0002265 astrocyte activation involved in immune response
GO:0002282 microglial cell activation involved in immune response
GO:0003723 RNA binding
GO:0005125 cytokine activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0005770 late endosome
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0007040 lysosome organization
GO:0007041 lysosomal transport
GO:0007042 lysosomal lumen acidification
GO:0007165 signal transduction
GO:0008083 growth factor activity
GO:0010595 positive regulation of endothelial cell migration
GO:0016020 membrane
GO:0030335 positive regulation of cell migration
GO:0035578 azurophil granule lumen
GO:0043312 neutrophil degranulation
GO:0043524 negative regulation of neuron apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0045766 positive regulation of angiogenesis
GO:0048680 positive regulation of axon regeneration
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050727 regulation of inflammatory response
GO:0050821 protein stabilization
GO:0051087 chaperone binding
GO:0060266 negative regulation of respiratory burst involved in inflammatory response
GO:0070062 extracellular exosome
GO:0106016 positive regulation of inflammatory response to wounding
GO:1900426 positive regulation of defense response to bacterium
GO:1902564 negative regulation of neutrophil activation
GO:1903334 positive regulation of protein folding
GO:1903979 negative regulation of microglial cell activation
GO:1905247 positive regulation of aspartic-type peptidase activity
GO:1905673 positive regulation of lysosome organization

Subcellular Location

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Subcellular Location
Lysosome
Secreted

Domains

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DomainNameCategoryType
IPR000118 GranulinDomainDomain
IPR037277 Granulin superfamilyFamilyHomologous superfamily
IPR039036 Granulin familyFamilyFamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
GRN_HUMANHXA1_MOUSEIntAct23088713 details