Entity Details

Primary name TNR8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP28908
EntryNameTNR8_HUMAN
FullNameTumor necrosis factor receptor superfamily member 8
TaxID9606
Evidenceevidence at protein level
Length595
SequenceStatuscomplete
DateCreated1992-12-01
DateModified2021-06-02

Ontological Relatives

GenesTNFRSF8

GO terms

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GOName
GO:0004888 transmembrane signaling receptor activity
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0007165 signal transduction
GO:0008285 negative regulation of cell population proliferation
GO:0016021 integral component of membrane
GO:0032759 positive regulation of TRAIL production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0043065 positive regulation of apoptotic process
GO:0070062 extracellular exosome
GO:0071260 cellular response to mechanical stimulus

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR001368 TNFR/NGFR cysteine-rich regionDomainDomain
IPR020416 Tumour necrosis factor receptor 8FamilyFamily
IPR034002 Tumour necrosis factor receptor 8, N-terminalDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB06324 XmAb 2513Drugbankbiotech
DB08870 Brentuximab vedotinDrugbankbiotech

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
TNR8_HUMANTRAF1_MOUSEBioGRID, IntAct8627180 details
TNR8_HUMANTRAF2_MOUSEBioGRID, IntAct8627180 details