Entity Details

Primary name TYK2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP29597
EntryNameTYK2_HUMAN
FullNameNon-receptor tyrosine-protein kinase TYK2
TaxID9606
Evidenceevidence at protein level
Length1187
SequenceStatuscomplete
DateCreated1993-04-01
DateModified2021-06-02

Ontological Relatives

GenesTYK2

GO terms

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GOName
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005131 growth hormone receptor binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0006468 protein phosphorylation
GO:0016020 membrane
GO:0019221 cytokine-mediated signaling pathway
GO:0031702 type 1 angiotensin receptor binding
GO:0035556 intracellular signal transduction
GO:0035722 interleukin-12-mediated signaling pathway
GO:0038155 interleukin-23-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
GO:0070062 extracellular exosome
GO:0070106 interleukin-27-mediated signaling pathway

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000299 FERM domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR016045 Tyrosine-protein kinase, non-receptor, TYK2, N-terminalDomainDomain
IPR016251 Tyrosine-protein kinase, non-receptor Jak/Tyk2FamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR019749 Band 4.1 domainDomainDomain
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR035963 FERM superfamily, second domainFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily
IPR041046 JAK, FERM F2 lobe domainDomainDomain
IPR041155 FERM F1 lobe ubiquitin-like domainDomainDomain
IPR041381 Jak1, pleckstrin homology-like domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB04716 2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-oneDrugbanksmall molecule
DB08895 TofacitinibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

0 interactions

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