Entity Details

Primary name PRDX6_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP30041
EntryNamePRDX6_HUMAN
FullNamePeroxiredoxin-6
TaxID9606
Evidenceevidence at protein level
Length224
SequenceStatuscomplete
DateCreated1993-04-01
DateModified2021-06-02

Ontological Relatives

GenesPRDX6

GO terms

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GOName
GO:0004602 glutathione peroxidase activity
GO:0004623 phospholipase A2 activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006979 response to oxidative stress
GO:0016020 membrane
GO:0031625 ubiquitin protein ligase binding
GO:0034599 cellular response to oxidative stress
GO:0035578 azurophil granule lumen
GO:0042744 hydrogen peroxide catabolic process
GO:0042802 identical protein binding
GO:0043312 neutrophil degranulation
GO:0045296 cadherin binding
GO:0045454 cell redox homeostasis
GO:0046475 glycerophospholipid catabolic process
GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity
GO:0047499 calcium-independent phospholipase A2 activity
GO:0048026 positive regulation of mRNA splicing, via spliceosome
GO:0048471 perinuclear region of cytoplasm
GO:0051920 peroxiredoxin activity
GO:0070062 extracellular exosome
GO:0098869 cellular oxidant detoxification
GO:0102567 phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)
GO:0102568 phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)

Subcellular Location

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Subcellular Location
Cytoplasm
Lysosome

Domains

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DomainNameCategoryType
IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidantDomainDomain
IPR013766 Thioredoxin domainDomainDomain
IPR019479 Peroxiredoxin, C-terminalDomainDomain
IPR024706 Peroxiredoxin, AhpC-typeFamilyFamily
IPR036249 Thioredoxin-like superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB03814 2-(N-morpholino)ethanesulfonic acidDrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
PRDX6_HUMANNCF2_MOUSEIntAct23401562 details
PRDX6_HUMANMK13_MOUSEBioGRID19135240 details