Entity Details

Primary name 2AAA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP30153
EntryName2AAA_HUMAN
FullNameSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
TaxID9606
Evidenceevidence at protein level
Length589
SequenceStatuscomplete
DateCreated1993-04-01
DateModified2021-06-02

Ontological Relatives

GenesPPP2R1A

GO terms

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GOName
GO:0000086 G2/M transition of mitotic cell cycle
GO:0005829 cytosol
GO:0006915 apoptotic process
GO:0008287 protein serine/threonine phosphatase complex
GO:0016328 lateral plasma membrane
GO:0019888 protein phosphatase regulator activity
GO:0030308 negative regulation of cell growth
GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein
GO:0006275 regulation of DNA replication
GO:0006672 ceramide metabolic process
GO:0007084 mitotic nuclear membrane reassembly
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0019932 second-messenger-mediated signaling
GO:0070062 extracellular exosome
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000188 obsolete inactivation of MAPK activity
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0007059 chromosome segregation
GO:0008380 RNA splicing
GO:0010033 response to organic substance
GO:0030155 regulation of cell adhesion
GO:0030425 dendrite
GO:0040008 regulation of growth
GO:0045595 regulation of cell differentiation
GO:0065003 protein-containing complex assembly
GO:1990405 protein antigen binding
GO:0000159 protein phosphatase type 2A complex
GO:0000775 chromosome, centromeric region
GO:0005737 cytoplasm
GO:0006355 regulation of transcription, DNA-templated
GO:0006470 protein dephosphorylation
GO:0015630 microtubule cytoskeleton
GO:0016020 membrane
GO:0030111 regulation of Wnt signaling pathway
GO:0046982 protein heterodimerization activity
GO:0097711 ciliary basal body-plasma membrane docking

Subcellular Location

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Subcellular Location
Cytoplasm
Lateral cell membrane
Chromosome
Nucleus
Cell projection

Domains

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DomainNameCategoryType
IPR000357 HEAT repeatRepeatRepeat
IPR011989 Armadillo-like helicalFamilyHomologous superfamily
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR021133 HEAT, type 2RepeatRepeat
IPR031090 Serine/threonine-protein phosphatase 2A subunit A, metazoaFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB02506 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic AcidDrugbanksmall molecule
DB06905 (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acidDrugbanksmall molecule