Entity Details

Primary name WEE1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP30291
EntryNameWEE1_HUMAN
FullNameWee1-like protein kinase
TaxID9606
Evidenceevidence at protein level
Length646
SequenceStatuscomplete
DateCreated1993-04-01
DateModified2021-06-02

Ontological Relatives

GenesWEE1

GO terms

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GOName
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000226 microtubule cytoskeleton organization
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0030010 establishment of cell polarity
GO:0048812 neuron projection morphogenesis
GO:0051301 cell division
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017164 Wee1-like protein kinaseFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

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Drugs

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DrugNameSourceType
DB04608 9-HYDROXY-4-PHENYL-6H-PYRROLO[3,4-C]CARBAZOLE-1,3-DIONEDrugbanksmall molecule
DB07006 9-HYDROXY-6-(3-HYDROXYPROPYL)-4-(2-METHOXYPHENYL)PYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONEDrugbanksmall molecule
DB07226 N-[4-(2-CHLOROPHENYL)-1,3-DIOXO-1,2,3,6-TETRAHYDROPYRROLO[3,4-C]CARBAZOL-9-YL]FORMAMIDEDrugbanksmall molecule
DB07257 4-(2-chlorophenyl)-8-(2-hydroxyethyl)-6-methylpyrrolo[3,4-e]indole-1,3(2H,6H)-dioneDrugbanksmall molecule
DB07265 3-(9-HYDROXY-1,3-DIOXO-4-PHENYL-2,3-DIHYDROPYRROLO[3,4-C]CARBAZOL-6(1H)-YL)PROPANOIC ACIDDrugbanksmall molecule
DB08365 8-bromo-4-(2-chlorophenyl)-N-(2-hydroxyethyl)-6-methyl-1,3-dioxo-1,2,3,6-tetrahydropyrrolo[3,4-e]indole-7-carboxamideDrugbanksmall molecule
DB11740 MK-1775Drugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
WEE1_HUMAN1433Z_MOUSEMINT9016762 details