Entity Details

Primary name AMRP_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP30533
EntryNameAMRP_HUMAN
FullNameAlpha-2-macroglobulin receptor-associated protein
TaxID9606
Evidenceevidence at protein level
Length357
SequenceStatuscomplete
DateCreated1993-04-01
DateModified2021-06-02

Ontological Relatives

GenesLRPAP1

GO terms

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GOName
GO:0001540 amyloid-beta binding
GO:0002091 negative regulation of receptor internalization
GO:0005102 signaling receptor binding
GO:0005576 extracellular region
GO:0005768 endosome
GO:0005783 endoplasmic reticulum
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0005794 Golgi apparatus
GO:0005796 Golgi lumen
GO:0005801 cis-Golgi network
GO:0005886 plasma membrane
GO:0007165 signal transduction
GO:0008201 heparin binding
GO:0009986 cell surface
GO:0010916 negative regulation of very-low-density lipoprotein particle clearance
GO:0012505 endomembrane system
GO:0031904 endosome lumen
GO:0032091 negative regulation of protein binding
GO:0035473 lipase binding
GO:0048018 receptor ligand activity
GO:0048019 receptor antagonist activity
GO:0048237 rough endoplasmic reticulum lumen
GO:0048259 regulation of receptor-mediated endocytosis
GO:0050750 low-density lipoprotein particle receptor binding
GO:0060548 negative regulation of cell death
GO:0070326 very-low-density lipoprotein particle receptor binding
GO:0150093 amyloid-beta clearance by transcytosis
GO:1900116 extracellular negative regulation of signal transduction
GO:1900222 negative regulation of amyloid-beta clearance
GO:1900223 positive regulation of amyloid-beta clearance

Subcellular Location

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Subcellular Location
Cell surface
Endoplasmic reticulum-Golgi intermediate compartment lumen
Endosome lumen
Golgi apparatus
Golgi apparatus lumen
Rough endoplasmic reticulum lumen

Domains

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DomainNameCategoryType
IPR009066 Alpha-2-macroglobulin receptor-associated protein, domain 1DomainDomain
IPR010483 Alpha-2-macroglobulin RAP, C-terminalDomainDomain
IPR036744 RAP domain superfamilyFamilyHomologous superfamily
IPR037999 Alpha-2-macroglobulin RAP, domain 3DomainDomain
IPR038001 Alpha-2-macroglobulin RAP, domain 2DomainDomain
IPR038003 Alpha-2-macroglobulin receptor-associated proteinFamilyFamily

Diseases

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Interactions

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