Entity Details

Primary name RPB2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP30876
EntryNameRPB2_HUMAN
FullNameDNA-directed RNA polymerase II subunit RPB2
TaxID9606
Evidenceevidence at protein level
Length1174
SequenceStatuscomplete
DateCreated1993-07-01
DateModified2021-06-02

Ontological Relatives

GenesPOLR2B

GO terms

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GOName
GO:0000398 mRNA splicing, via spliceosome
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003723 RNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005665 RNA polymerase II, core complex
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006351 transcription, DNA-templated
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0006370 7-methylguanosine mRNA capping
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0016020 membrane
GO:0016070 RNA metabolic process
GO:0032549 ribonucleoside binding
GO:0042795 snRNA transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0048239 negative regulation of DNA recombination at telomere
GO:0050434 positive regulation of viral transcription
GO:0060964 regulation of gene silencing by miRNA

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR007120 DNA-directed RNA polymerase, subunit 2, hybrid-binding domainDomainDomain
IPR007121 RNA polymerase, beta subunit, conserved siteSiteConserved site
IPR007641 RNA polymerase Rpb2, domain 7DomainDomain
IPR007642 RNA polymerase Rpb2, domain 2DomainDomain
IPR007644 RNA polymerase, beta subunit, protrusionDomainDomain
IPR007645 RNA polymerase Rpb2, domain 3DomainDomain
IPR007646 RNA polymerase Rpb2, domain 4DomainDomain
IPR007647 RNA polymerase Rpb2, domain 5DomainDomain
IPR014724 RNA polymerase Rpb2, OB-foldFamilyHomologous superfamily
IPR015712 DNA-directed RNA polymerase, subunit 2FamilyFamily
IPR037033 DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamilyFamilyHomologous superfamily
IPR037034 RNA polymerase Rpb2, domain 2 superfamilyFamilyHomologous superfamily

Diseases

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Interactions

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