Entity Details

Primary name AKT1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP31749
EntryNameAKT1_HUMAN
FullNameRAC-alpha serine/threonine-protein kinase
TaxID9606
Evidenceevidence at protein level
Length480
SequenceStatuscomplete
DateCreated1993-07-01
DateModified2021-06-02

Ontological Relatives

GenesAKT1

GO terms

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GOName
GO:0001938 positive regulation of endothelial cell proliferation
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0006468 protein phosphorylation
GO:0006924 activation-induced cell death of T cells
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007281 germ cell development
GO:0007568 aging
GO:0008286 insulin receptor signaling pathway
GO:0010761 fibroblast migration
GO:0010907 positive regulation of glucose metabolic process
GO:0010975 regulation of neuron projection development
GO:0015630 microtubule cytoskeleton
GO:0016301 kinase activity
GO:0018105 peptidyl-serine phosphorylation
GO:0019899 enzyme binding
GO:0030235 nitric-oxide synthase regulator activity
GO:0030307 positive regulation of cell growth
GO:0031295 T cell costimulation
GO:0032270 positive regulation of cellular protein metabolic process
GO:0032929 negative regulation of superoxide anion generation
GO:0034405 response to fluid shear stress
GO:0038061 NIK/NF-kappaB signaling
GO:0042981 regulation of apoptotic process
GO:0043276 anoikis
GO:0043491 protein kinase B signaling
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0045907 positive regulation of vasoconstriction
GO:0046329 negative regulation of JNK cascade
GO:0046622 positive regulation of organ growth
GO:0046777 protein autophosphorylation
GO:0046889 positive regulation of lipid biosynthetic process
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050999 regulation of nitric-oxide synthase activity
GO:0051146 striated muscle cell differentiation
GO:0051898 negative regulation of protein kinase B signaling
GO:0060716 labyrinthine layer blood vessel development
GO:0071276 cellular response to cadmium ion
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0071889 14-3-3 protein binding
GO:0072655 establishment of protein localization to mitochondrion
GO:0090201 negative regulation of release of cytochrome c from mitochondria
GO:0099104 potassium channel activator activity
GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:1903715 regulation of aerobic respiration
GO:1990090 cellular response to nerve growth factor stimulus
GO:0001934 positive regulation of protein phosphorylation
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0006954 inflammatory response
GO:0006974 cellular response to DNA damage stimulus
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0008284 positive regulation of cell population proliferation
GO:0008637 apoptotic mitochondrial changes
GO:0010507 negative regulation of autophagy
GO:0010918 positive regulation of mitochondrial membrane potential
GO:0010951 negative regulation of endopeptidase activity
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0016242 negative regulation of macroautophagy
GO:0016567 protein ubiquitination
GO:0018107 peptidyl-threonine phosphorylation
GO:0021510 spinal cord development
GO:0031641 regulation of myelination
GO:0031982 vesicle
GO:0032094 response to food
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0042593 glucose homeostasis
GO:0043065 positive regulation of apoptotic process
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045600 positive regulation of fat cell differentiation
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway
GO:0045746 negative regulation of Notch signaling pathway
GO:0045792 negative regulation of cell size
GO:0045861 negative regulation of proteolysis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046146 tetrahydrobiopterin metabolic process
GO:0051721 protein phosphatase 2A binding
GO:0060644 mammary gland epithelial cell differentiation
GO:0060709 glycogen cell differentiation involved in embryonic placenta development
GO:0070848 response to growth factor
GO:0071260 cellular response to mechanical stimulus
GO:0071356 cellular response to tumor necrosis factor
GO:0071380 cellular response to prostaglandin E stimulus
GO:0072656 maintenance of protein location in mitochondrion
GO:0098794 postsynapse
GO:0100002 negative regulation of protein kinase activity by protein phosphorylation
GO:0110099 negative regulation of calcium import into the mitochondrion
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1903038 negative regulation of leukocyte cell-cell adhesion
GO:1903078 positive regulation of protein localization to plasma membrane
GO:1903721 positive regulation of I-kappaB phosphorylation
GO:1990418 response to insulin-like growth factor stimulus
GO:2000010 positive regulation of protein localization to cell surface
GO:2000074 regulation of type B pancreatic cell development
GO:2000402 negative regulation of lymphocyte migration
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:0005524 ATP binding
GO:0005886 plasma membrane
GO:0005978 glycogen biosynthetic process
GO:0006006 glucose metabolic process
GO:0006469 negative regulation of protein kinase activity
GO:0006606 protein import into nucleus
GO:0006809 nitric oxide biosynthetic process
GO:0006979 response to oxidative stress
GO:0009408 response to heat
GO:0010629 negative regulation of gene expression
GO:0010748 negative regulation of long-chain fatty acid import across plasma membrane
GO:0010763 positive regulation of fibroblast migration
GO:0019221 cytokine-mediated signaling pathway
GO:0030163 protein catabolic process
GO:0030212 hyaluronan metabolic process
GO:0030334 regulation of cell migration
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031999 negative regulation of fatty acid beta-oxidation
GO:0032148 activation of protein kinase B activity
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032869 cellular response to insulin stimulus
GO:0034614 cellular response to reactive oxygen species
GO:0035556 intracellular signal transduction
GO:0036064 ciliary basal body
GO:0042803 protein homodimerization activity
GO:0043066 negative regulation of apoptotic process
GO:0046326 positive regulation of glucose import
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0060079 excitatory postsynaptic potential
GO:0071407 cellular response to organic cyclic compound
GO:0071901 negative regulation of protein serine/threonine kinase activity
GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus
GO:0097194 execution phase of apoptosis
GO:0106310 protein serine kinase activity
GO:0001649 osteoblast differentiation
GO:0001893 maternal placenta development
GO:0002042 cell migration involved in sprouting angiogenesis
GO:0002931 response to ischemia
GO:0003376 sphingosine-1-phosphate receptor signaling pathway
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005080 protein kinase C binding
GO:0005516 calmodulin binding
GO:0005829 cytosol
GO:0005911 cell-cell junction
GO:0005979 regulation of glycogen biosynthetic process
GO:0006412 translation
GO:0006417 regulation of translation
GO:0008283 cell population proliferation
GO:0008643 carbohydrate transport
GO:0010595 positive regulation of endothelial cell migration
GO:0010628 positive regulation of gene expression
GO:0010765 positive regulation of sodium ion transport
GO:0016310 phosphorylation
GO:0030027 lamellipodium
GO:0030030 cell projection organization
GO:0030154 cell differentiation
GO:0031397 negative regulation of protein ubiquitination
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0031929 TOR signaling
GO:0032079 positive regulation of endodeoxyribonuclease activity
GO:0032091 negative regulation of protein binding
GO:0032287 peripheral nervous system myelin maintenance
GO:0032794 GTPase activating protein binding
GO:0032991 protein-containing complex
GO:0035655 interleukin-18-mediated signaling pathway
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0042802 identical protein binding
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043488 regulation of mRNA stability
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045893 positive regulation of transcription, DNA-templated
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0060416 response to growth hormone
GO:0070141 response to UV-A
GO:0071456 cellular response to hypoxia
GO:0106311 protein threonine kinase activity
GO:0140052 cellular response to oxidised low-density lipoprotein particle stimulus
GO:1900182 positive regulation of protein localization to nucleus
GO:1901215 negative regulation of neuron death

Subcellular Location

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Subcellular Location
Cell membrane
Nucleus
Cytoplasm

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000961 AGC-kinase, C-terminalDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR017892 Protein kinase, C-terminalDomainDomain
IPR034676 Protein kinase B alpha, catalytic domainDomainDomain
IPR039026 Protein Kinase B, pleckstrin homology domainDomainDomain
IPR039027 Serine/threonine-protein kinase RAC alphaFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB00171 ATPDrugbanksmall molecule
DB01169 Arsenic trioxideDrugbanksmall molecule
DB01645 GenisteinDrugbanksmall molecule
DB01863 Inositol 1,3,4,5-TetrakisphosphateDrugbanksmall molecule
DB02709 ResveratrolDrugbanksmall molecule
DB05971 ArchexinDrugbanksmall molecule
DB06486 EnzastaurinDrugbanksmall molecule
DB06641 PerifosineDrugbanksmall molecule
DB07584 N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amineDrugbanksmall molecule
DB07585 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridineDrugbanksmall molecule

Interactions

5 interactions