Entity Details

Primary name GRK5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP34947
EntryNameGRK5_HUMAN
FullNameG protein-coupled receptor kinase 5
TaxID9606
Evidenceevidence at protein level
Length590
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesGRK5

GO terms

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GOName
GO:0004674 protein serine/threonine kinase activity
GO:0004703 G protein-coupled receptor kinase activity
GO:0005080 protein kinase C binding
GO:0005524 ATP binding
GO:0005543 phospholipid binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006915 apoptotic process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO:0007217 tachykinin receptor signaling pathway
GO:0008277 regulation of G protein-coupled receptor signaling pathway
GO:0008284 positive regulation of cell population proliferation
GO:0016055 Wnt signaling pathway
GO:0016607 nuclear speck
GO:0031965 nuclear membrane
GO:0043066 negative regulation of apoptotic process
GO:0046777 protein autophosphorylation
GO:0047696 beta-adrenergic receptor kinase activity
GO:0051726 regulation of cell cycle

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000239 GPCR kinaseFamilyFamily
IPR000719 Protein kinase domainDomainDomain
IPR000961 AGC-kinase, C-terminalDomainDomain
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR016137 RGS domainDomainDomain
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR036305 RGS domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
GRK5_HUMAN5HT4R_MOUSEMINT19661922 details