Entity Details

Primary name MERL_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP35240
EntryNameMERL_HUMAN
FullNameMerlin
TaxID9606
Evidenceevidence at protein level
Length595
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesNF2

GO terms

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GOName
GO:0001707 mesoderm formation
GO:0001953 negative regulation of cell-matrix adhesion
GO:0003779 actin binding
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005912 adherens junction
GO:0006469 negative regulation of protein kinase activity
GO:0007398 ectoderm development
GO:0008285 negative regulation of cell population proliferation
GO:0014010 Schwann cell proliferation
GO:0014013 regulation of gliogenesis
GO:0016020 membrane
GO:0021766 hippocampus development
GO:0022408 negative regulation of cell-cell adhesion
GO:0030027 lamellipodium
GO:0030036 actin cytoskeleton organization
GO:0030336 negative regulation of cell migration
GO:0030864 cortical actin cytoskeleton
GO:0031527 filopodium membrane
GO:0031647 regulation of protein stability
GO:0032154 cleavage furrow
GO:0032587 ruffle membrane
GO:0035330 regulation of hippo signaling
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein
GO:0042981 regulation of apoptotic process
GO:0043005 neuron projection
GO:0043409 negative regulation of MAPK cascade
GO:0044297 cell body
GO:0045177 apical part of cell
GO:0045216 cell-cell junction organization
GO:0045597 positive regulation of cell differentiation
GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT
GO:0048471 perinuclear region of cytoplasm
GO:0051496 positive regulation of stress fiber assembly
GO:0051726 regulation of cell cycle
GO:0070306 lens fiber cell differentiation
GO:0072091 regulation of stem cell proliferation
GO:1900180 regulation of protein localization to nucleus
GO:2000177 regulation of neural precursor cell proliferation

Subcellular Location

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Subcellular Location
Cell projection
Cytoplasm
Cytoplasmic granule
Nucleus

Domains

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DomainNameCategoryType
IPR000299 FERM domainDomainDomain
IPR000798 Ezrin/radixin/moesin-likeFamilyFamily
IPR008954 Moesin tail domain superfamilyFamilyHomologous superfamily
IPR011174 Ezrin/radixin/moesinFamilyFamily
IPR011259 Ezrin/radixin/moesin, C-terminalDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR014352 FERM/acyl-CoA-binding protein superfamilyFamilyHomologous superfamily
IPR018979 FERM, N-terminalDomainDomain
IPR018980 FERM, C-terminal PH-like domainDomainDomain
IPR019747 FERM conserved siteSiteConserved site
IPR019748 FERM central domainDomainDomain
IPR019749 Band 4.1 domainDomainDomain
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily
IPR035963 FERM superfamily, second domainFamilyHomologous superfamily
IPR041789 ERM family, FERM domain C-lobeDomainDomain

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
MERL_HUMANSCHI1_MOUSEBioGRID, UniProt10669747 details
MERL_HUMANKSR1_MOUSEBioGRID26549023 details