Entity Details

Primary name RFC1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP35251
EntryNameRFC1_HUMAN
FullNameReplication factor C subunit 1
TaxID9606
Evidenceevidence at protein level
Length1148
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesRFC1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0003677 DNA binding
GO:0003689 DNA clamp loader activity
GO:0003690 double-stranded DNA binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005663 DNA replication factor C complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0006261 DNA-dependent DNA replication
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006287 base-excision repair, gap-filling
GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006297 nucleotide-excision repair, DNA gap filling
GO:0007004 telomere maintenance via telomerase
GO:0008047 enzyme activator activity
GO:0019904 protein domain specific binding
GO:0019985 translesion synthesis
GO:0031391 Elg1 RFC-like complex
GO:0032201 telomere maintenance via semi-conservative replication
GO:0033683 nucleotide-excision repair, DNA incision
GO:0042276 error-prone translesion synthesis
GO:0042769 DNA damage response, detection of DNA damage
GO:0043565 sequence-specific DNA binding
GO:0045893 positive regulation of transcription, DNA-templated
GO:0061860 DNA clamp unloader activity
GO:0070062 extracellular exosome
GO:0070987 error-free translesion synthesis
GO:0090618 DNA clamp unloading

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001357 BRCT domainDomainDomain
IPR003593 AAA+ ATPase domainDomainDomain
IPR003959 ATPase, AAA-type, coreDomainDomain
IPR008921 DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminalFamilyHomologous superfamily
IPR012178 Replication factor C subunit 1FamilyFamily
IPR013725 DNA replication factor RFC1, C-terminalDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR036420 BRCT domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

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