Entity Details

Primary name IRS1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP35568
EntryNameIRS1_HUMAN
FullNameInsulin receptor substrate 1
TaxID9606
Evidenceevidence at protein level
Length1242
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesIRS1

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001784 phosphotyrosine residue binding
GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005080 protein kinase C binding
GO:0005158 insulin receptor binding
GO:0005159 insulin-like growth factor receptor binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005899 insulin receptor complex
GO:0005901 caveola
GO:0007165 signal transduction
GO:0008284 positive regulation of cell population proliferation
GO:0008286 insulin receptor signaling pathway
GO:0010907 positive regulation of glucose metabolic process
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0030159 signaling receptor complex adaptor activity
GO:0032000 positive regulation of fatty acid beta-oxidation
GO:0032868 response to insulin
GO:0032869 cellular response to insulin stimulus
GO:0038111 interleukin-7-mediated signaling pathway
GO:0042169 SH2 domain binding
GO:0042593 glucose homeostasis
GO:0043231 intracellular membrane-bounded organelle
GO:0043434 response to peptide hormone
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0046326 positive regulation of glucose import
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0046676 negative regulation of insulin secretion
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0051897 positive regulation of protein kinase B signaling
GO:0071398 cellular response to fatty acid

Subcellular Location

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Domains

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DomainNameCategoryType
IPR001849 Pleckstrin homology domainDomainDomain
IPR002404 IRS-type PTB domainDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR039011 Insulin receptor substrateFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB08513 [4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACIDDrugbanksmall molecule