Entity Details

Primary name AHR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP35869
EntryNameAHR_HUMAN
FullNameAryl hydrocarbon receptor
TaxID9606
Evidenceevidence at protein level
Length848
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesAHR

GO terms

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GOName
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 cis-regulatory region sequence-specific DNA binding
GO:0001094 TFIID-class transcription factor complex binding
GO:0001223 transcription coactivator binding
GO:0001568 blood vessel development
GO:0002819 regulation of adaptive immune response
GO:0002841 negative regulation of T cell mediated immune response to tumor cell
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0004879 nuclear receptor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006805 xenobiotic metabolic process
GO:0006915 apoptotic process
GO:0007049 cell cycle
GO:0008134 transcription factor binding
GO:0009410 response to xenobiotic stimulus
GO:0009636 response to toxic substance
GO:0010468 regulation of gene expression
GO:0017025 TBP-class protein binding
GO:0019933 cAMP-mediated signaling
GO:0030888 regulation of B cell proliferation
GO:0032922 circadian regulation of gene expression
GO:0032991 protein-containing complex
GO:0034751 aryl hydrocarbon receptor complex
GO:0034752 cytosolic aryl hydrocarbon receptor complex
GO:0042803 protein homodimerization activity
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046982 protein heterodimerization activity
GO:0051879 Hsp90 protein binding
GO:0070888 E-box binding
GO:0071320 cellular response to cAMP
GO:1904322 cellular response to forskolin
GO:1904613 cellular response to 2,3,7,8-tetrachlorodibenzodioxine
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000014 PAS domainDomainDomain
IPR001610 PAC motifRepeatRepeat
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domainDomainDomain
IPR013655 PAS fold-3DomainDomain
IPR013767 PAS foldDomainDomain
IPR033348 Aryl hydrocarbon receptorFamilyFamily
IPR035965 PAS domain superfamilyFamilyHomologous superfamily
IPR036638 Helix-loop-helix DNA-binding domain superfamilyFamilyHomologous superfamily
IPR039091 Aryl hydrocarbon receptor/Aryl hydrocarbon receptor repressorFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB00338 OmeprazoleDrugbanksmall molecule
DB00379 MexiletineDrugbanksmall molecule
DB00393 NimodipineDrugbanksmall molecule
DB00499 FlutamideDrugbanksmall molecule
DB01076 AtorvastatinDrugbanksmall molecule
DB01097 LeflunomideDrugbanksmall molecule
DB01404 GinsengDrugbanksmall molecule
DB02052 Indirubin-3'-monoximeDrugbanksmall molecule
DB02709 ResveratrolDrugbanksmall molecule
DB04216 QuercetinDrugbanksmall molecule
DB06732 beta-NaphthoflavoneDrugbanksmall molecule
DB07715 EmodinDrugbanksmall molecule
DB08624 1-[(4S)-4-amino-5-(1,3-benzothiazol-2-yl)-5-oxopentyl]guanidineDrugbanksmall molecule
DB08995 DiosminDrugbanksmall molecule
DB11577 Indigotindisulfonic acidDrugbanksmall molecule
DB11937 Kynurenic AcidDrugbanksmall molecule
DB12116 Epigallocatechin gallateDrugbanksmall molecule
DB12328 CantharidinDrugbanksmall molecule
DB12379 IndirubinDrugbanksmall molecule

Interactions

0 interactions

InteractorPartnerSourcesPublicationsLink