Entity Details

Primary name MP2K2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP36507
EntryNameMP2K2_HUMAN
FullNameDual specificity mitogen-activated protein kinase kinase 2
TaxID9606
Evidenceevidence at protein level
Length400
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesMAP2K2

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000186 obsolete activation of MAPKK activity
GO:0000187 obsolete activation of MAPK activity
GO:0004708 MAP kinase kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005078 MAP-kinase scaffold activity
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005778 peroxisomal membrane
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005874 microtubule
GO:0005911 cell-cell junction
GO:0005925 focal adhesion
GO:0009898 cytoplasmic side of plasma membrane
GO:0010629 negative regulation of gene expression
GO:0030165 PDZ domain binding
GO:0032872 regulation of stress-activated MAPK cascade
GO:0036289 peptidyl-serine autophosphorylation
GO:0043539 protein serine/threonine kinase activator activity
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046872 metal ion binding
GO:0048471 perinuclear region of cytoplasm
GO:0070371 ERK1 and ERK2 cascade
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0090170 regulation of Golgi inheritance
GO:0097110 scaffold protein binding
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA
GO:2000641 regulation of early endosome to late endosome transport

Subcellular Location

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Subcellular Location
Cytoplasm
Membrane

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

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Drugs

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DrugNameSourceType
DB06616 BosutinibDrugbanksmall molecule
DB08911 TrametinibDrugbanksmall molecule
DB11689 SelumetinibDrugbanksmall molecule
DB11967 BinimetinibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
MP2K2_HUMANKSR1_MOUSEBioGRID, MINT10409742 26549023 details
MP2K2_HUMANFLNA_MOUSEBioGRID9006895 details