Entity Details

Primary name ACV1B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP36896
EntryNameACV1B_HUMAN
FullNameActivin receptor type-1B
TaxID9606
Evidenceevidence at protein level
Length505
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesACVR1B

GO terms

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GOName
GO:0000082 G1/S transition of mitotic cell cycle
GO:0001701 in utero embryonic development
GO:0001942 hair follicle development
GO:0004674 protein serine/threonine kinase activity
GO:0004675 transmembrane receptor protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007399 nervous system development
GO:0007417 central nervous system development
GO:0009986 cell surface
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0016361 activin receptor activity, type I
GO:0018107 peptidyl-threonine phosphorylation
GO:0030308 negative regulation of cell growth
GO:0031625 ubiquitin protein ligase binding
GO:0032924 activin receptor signaling pathway
GO:0032927 positive regulation of activin receptor signaling pathway
GO:0034711 inhibin binding
GO:0038092 nodal signaling pathway
GO:0043235 receptor complex
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046332 SMAD binding
GO:0046545 development of primary female sexual characteristics
GO:0046777 protein autophosphorylation
GO:0046872 metal ion binding
GO:0048179 activin receptor complex
GO:0048185 activin binding
GO:0071363 cellular response to growth factor stimulus
GO:0097191 extrinsic apoptotic signaling pathway
GO:1901165 positive regulation of trophoblast cell migration

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000333 Ser/Thr protein kinase, TGFB receptorFamilyFamily
IPR000472 Activin types I and II receptor domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR003605 GS domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

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Drugs

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DrugNameSourceType
DB00171 ATPDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

3 interactions