Entity Details

Primary name PPARG_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP37231
EntryNamePPARG_HUMAN
FullNamePeroxisome proliferator-activated receptor gamma
TaxID9606
Evidenceevidence at protein level
Length505
SequenceStatuscomplete
DateCreated1994-10-01
DateModified2021-06-02

Ontological Relatives

GenesPPARG

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001890 placenta development
GO:0002674 negative regulation of acute inflammatory response
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0004879 nuclear receptor activity
GO:0004955 prostaglandin receptor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006629 lipid metabolic process
GO:0006631 fatty acid metabolic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007165 signal transduction
GO:0007507 heart development
GO:0007584 response to nutrient
GO:0008022 protein C-terminus binding
GO:0008134 transcription factor binding
GO:0008217 regulation of blood pressure
GO:0008270 zinc ion binding
GO:0009409 response to cold
GO:0009612 response to mechanical stimulus
GO:0009755 hormone-mediated signaling pathway
GO:0010742 macrophage derived foam cell differentiation
GO:0010745 negative regulation of macrophage derived foam cell differentiation
GO:0010887 negative regulation of cholesterol storage
GO:0010891 negative regulation of sequestering of triglyceride
GO:0015909 long-chain fatty acid transport
GO:0016525 negative regulation of angiogenesis
GO:0019216 regulation of lipid metabolic process
GO:0019395 fatty acid oxidation
GO:0019899 enzyme binding
GO:0019903 protein phosphatase binding
GO:0030154 cell differentiation
GO:0030224 monocyte differentiation
GO:0030308 negative regulation of cell growth
GO:0030331 estrogen receptor binding
GO:0030514 negative regulation of BMP signaling pathway
GO:0030855 epithelial cell differentiation
GO:0031000 response to caffeine
GO:0031100 animal organ regeneration
GO:0032869 cellular response to insulin stimulus
GO:0032966 negative regulation of collagen biosynthetic process
GO:0033189 response to vitamin A
GO:0033993 response to lipid
GO:0035357 peroxisome proliferator activated receptor signaling pathway
GO:0035902 response to immobilization stress
GO:0042277 peptide binding
GO:0042493 response to drug
GO:0042593 glucose homeostasis
GO:0042594 response to starvation
GO:0042752 regulation of circadian rhythm
GO:0042802 identical protein binding
GO:0042953 lipoprotein transport
GO:0043231 intracellular membrane-bounded organelle
GO:0043235 receptor complex
GO:0043388 positive regulation of DNA binding
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0043621 protein self-association
GO:0043627 response to estrogen
GO:0045087 innate immune response
GO:0045165 cell fate commitment
GO:0045600 positive regulation of fat cell differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045923 positive regulation of fatty acid metabolic process
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046321 positive regulation of fatty acid oxidation
GO:0046965 retinoid X receptor binding
GO:0048384 retinoic acid receptor signaling pathway
GO:0048469 cell maturation
GO:0048471 perinuclear region of cytoplasm
GO:0048511 rhythmic process
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0048714 positive regulation of oligodendrocyte differentiation
GO:0050544 arachidonic acid binding
GO:0050692 DNA binding domain binding
GO:0050693 LBD domain binding
GO:0050728 negative regulation of inflammatory response
GO:0050872 white fat cell differentiation
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051393 alpha-actinin binding
GO:0051974 negative regulation of telomerase activity
GO:0055088 lipid homeostasis
GO:0060100 positive regulation of phagocytosis, engulfment
GO:0060336 negative regulation of interferon-gamma-mediated signaling pathway
GO:0060694 regulation of cholesterol transporter activity
GO:0060965 negative regulation of gene silencing by miRNA
GO:0070888 E-box binding
GO:0071300 cellular response to retinoic acid
GO:0071306 cellular response to vitamin E
GO:0071380 cellular response to prostaglandin E stimulus
GO:0071404 cellular response to low-density lipoprotein particle stimulus
GO:0071455 cellular response to hyperoxia
GO:0090575 RNA polymerase II transcription regulator complex
GO:1901558 response to metformin
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation
GO:1905461 positive regulation of vascular associated smooth muscle cell apoptotic process
GO:1905563 negative regulation of vascular endothelial cell proliferation
GO:1905599 positive regulation of low-density lipoprotein receptor activity
GO:2000230 negative regulation of pancreatic stellate cell proliferation
GO:2000272 negative regulation of signaling receptor activity

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000536 Nuclear hormone receptor, ligand-binding domainDomainDomain
IPR001628 Zinc finger, nuclear hormone receptor-typeDomainDomain
IPR001723 Nuclear hormone receptorFamilyFamily
IPR003074 Peroxisome proliferator-activated receptorFamilyFamily
IPR003077 Peroxisome proliferator-activated receptor gammaFamilyFamily
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR022590 Peroxisome proliferator-activated receptor gamma, N-terminalDomainDomain
IPR035500 Nuclear hormone receptor-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00132 alpha-Linolenic acidDrugbanksmall molecule
DB00159 IcosapentDrugbanksmall molecule
DB00197 TroglitazoneDrugbanksmall molecule
DB00244 MesalazineDrugbanksmall molecule
DB00313 Valproic acidDrugbanksmall molecule
DB00328 IndomethacinDrugbanksmall molecule
DB00412 RosiglitazoneDrugbanksmall molecule
DB00573 FenoprofenDrugbanksmall molecule
DB00731 NateglinideDrugbanksmall molecule
DB00795 SulfasalazineDrugbanksmall molecule
DB00845 ClofazimineDrugbanksmall molecule
DB00912 RepaglinideDrugbanksmall molecule
DB00966 TelmisartanDrugbanksmall molecule
DB01014 BalsalazideDrugbanksmall molecule
DB01050 IbuprofenDrugbanksmall molecule
DB01067 GlipizideDrugbanksmall molecule
DB01118 AmiodaroneDrugbanksmall molecule
DB01132 PioglitazoneDrugbanksmall molecule
DB01252 MitiglinideDrugbanksmall molecule
DB01393 BezafibrateDrugbanksmall molecule
DB02266 Flufenamic acidDrugbanksmall molecule
DB02709 ResveratrolDrugbanksmall molecule
DB02746 Phthalic AcidDrugbanksmall molecule
DB03600 Capric acidDrugbanksmall molecule
DB03756 DoconexentDrugbanksmall molecule
DB04224 Oleic AcidDrugbanksmall molecule
DB04270 (S)-3-(4-(2-Carbazol-9-Yl-Ethoxy)-Phenyl)-2-Ethoxy-Propionic AcidDrugbanksmall molecule
DB04689 2-{5-[3-(6-BENZOYL-1-PROPYLNAPHTHALEN-2-YLOXY)PROPOXY]INDOL-1-YL}ETHANOIC ACIDDrugbanksmall molecule
DB04971 ReglitazarDrugbanksmall molecule
DB05187 ElafibranorDrugbanksmall molecule
DB05490 AMG-131Drugbanksmall molecule
DB05854 CLX-0921Drugbanksmall molecule
DB06510 MuraglitazarDrugbanksmall molecule
DB06521 ErtiprotafibDrugbanksmall molecule
DB06533 RagaglitazarDrugbanksmall molecule
DB06536 TesaglitazarDrugbanksmall molecule
DB06908 (2S)-3-(1-{[2-(2-CHLOROPHENYL)-5-METHYL-1,3-OXAZOL-4-YL]METHYL}-1H-INDOL-5-YL)-2-ETHOXYPROPANOIC ACIDDrugbanksmall molecule
DB06926 (9Z,11E,13S)-13-hydroxyoctadeca-9,11-dienoic acidDrugbanksmall molecule
DB07053 2-{5-[3-(7-PROPYL-3-TRIFLUOROMETHYLBENZO[D]ISOXAZOL-6-YLOXY)PROPOXY]INDOL-1-YL}ETHANOIC ACIDDrugbanksmall molecule
DB07111 (4S,5E,7Z,10Z,13Z,16Z,19Z)-4-hydroxydocosa-5,7,10,13,16,19-hexaenoic acidDrugbanksmall molecule
DB07172 (5R,6E,8Z,11Z,14Z,17Z)-5-hydroxyicosa-6,8,11,14,17-pentaenoic acidDrugbanksmall molecule
DB07208 (8E,10S,12Z)-10-hydroxy-6-oxooctadeca-8,12-dienoic acidDrugbanksmall molecule
DB07209 (8R,9Z,12Z)-8-hydroxy-6-oxooctadeca-9,12-dienoic acidDrugbanksmall molecule
DB07302 9(S)-HODEDrugbanksmall molecule
DB07509 difluoro(5-{2-[(5-octyl-1H-pyrrol-2-yl-kappaN)methylidene]-2H-pyrrol-5-yl-kappaN}pentanoato)boronDrugbanksmall molecule
DB07675 (2S)-2-ETHOXY-3-{4-[2-(10H-PHENOXAZIN-10-YL)ETHOXY]PHENYL}PROPANOIC ACIDDrugbanksmall molecule
DB07723 3-(5-methoxy-1H-indol-3-yl)propanoic acidDrugbanksmall molecule
DB07724 IndeglitazarDrugbanksmall molecule
DB07842 (2S)-2-(4-ethylphenoxy)-3-phenylpropanoic acidDrugbanksmall molecule
DB07863 2-chloro-5-nitro-N-phenylbenzamideDrugbanksmall molecule
DB08121 (2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acidDrugbanksmall molecule
DB08302 3-[5-(2-nitropent-1-en-1-yl)furan-2-yl]benzoic acidDrugbanksmall molecule
DB08402 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACIDDrugbanksmall molecule
DB08435 (5E,14E)-11-oxoprosta-5,9,12,14-tetraen-1-oic acidDrugbanksmall molecule
DB08560 3-FLUORO-N-[1-(4-FLUOROPHENYL)-3-(2-THIENYL)-1H-PYRAZOL-5-YL]BENZENESULFONAMIDEDrugbanksmall molecule
DB08604 TriclosanDrugbanksmall molecule
DB08760 (2S)-2-(4-chlorophenoxy)-3-phenylpropanoic acidDrugbanksmall molecule
DB08915 AleglitazarDrugbanksmall molecule
DB09006 ClinofibrateDrugbanksmall molecule
DB09061 CannabidiolDrugbanksmall molecule
DB09198 LobeglitazoneDrugbanksmall molecule
DB09201 CiglitazoneDrugbanksmall molecule
DB09213 DexibuprofenDrugbanksmall molecule
DB11133 Omega-3 fatty acidsDrugbanksmall molecule
DB11672 CurcuminDrugbanksmall molecule
DB11811 ArhalofenateDrugbanksmall molecule
DB12007 IsoflavoneDrugbanksmall molecule
DB12662 NaveglitazarDrugbanksmall molecule
DB13873 Fenofibric acidDrugbanksmall molecule
DB13961 Fish oilDrugbankbiotech
DB14009 Medical CannabisDrugbankbiotech
DB14011 NabiximolsDrugbanksmall molecule
DB14034 DarglitazoneDrugbanksmall molecule
DB14635 Curcumin sulfateDrugbanksmall molecule