Entity Details

Primary name FDFT_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP37268
EntryNameFDFT_HUMAN
FullNameSqualene synthase
TaxID9606
Evidenceevidence at protein level
Length417
SequenceStatuscomplete
DateCreated1994-10-01
DateModified2021-06-02

Ontological Relatives

GenesFDFT1

GO terms

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GOName
GO:0004310 farnesyl-diphosphate farnesyltransferase activity
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0006694 steroid biosynthetic process
GO:0006695 cholesterol biosynthetic process
GO:0016021 integral component of membrane
GO:0019216 regulation of lipid metabolic process
GO:0019222 regulation of metabolic process
GO:0045338 farnesyl diphosphate metabolic process
GO:0046872 metal ion binding
GO:0051996 squalene synthase activity

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR002060 Squalene/phytoene synthaseFamilyFamily
IPR006449 Squalene synthase-likeFamilyFamily
IPR008949 Isoprenoid synthase domain superfamilyFamilyHomologous superfamily
IPR019845 Squalene/phytoene synthase, conserved siteSiteConserved site
IPR033904 Trans-isoprenyl diphosphate synthases, head-to-headDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB05317 TAK-475Drugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
FDFT_HUMANRFLA_MOUSEBioGRID16169070 details