Entity Details

Primary name SYUA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP37840
EntryNameSYUA_HUMAN
FullNameAlpha-synuclein
TaxID9606
Evidenceevidence at protein level
Length140
SequenceStatuscomplete
DateCreated1994-10-01
DateModified2021-06-02

Ontological Relatives

GenesSNCA

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000149 SNARE binding
GO:0000287 magnesium ion binding
GO:0000976 transcription cis-regulatory region binding
GO:0001774 microglial cell activation
GO:0001921 positive regulation of receptor recycling
GO:0003779 actin binding
GO:0004860 protein kinase inhibitor activity
GO:0005507 copper ion binding
GO:0005509 calcium ion binding
GO:0005543 phospholipid binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005764 lysosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0006469 negative regulation of protein kinase activity
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007268 chemical synaptic transmission
GO:0008198 ferrous iron binding
GO:0008270 zinc ion binding
GO:0010040 response to iron(II) ion
GO:0010517 regulation of phospholipase activity
GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway
GO:0014059 regulation of dopamine secretion
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0016079 synaptic vesicle exocytosis
GO:0016082 synaptic vesicle priming
GO:0016234 inclusion body
GO:0016491 oxidoreductase activity
GO:0019894 kinesin binding
GO:0022898 regulation of transmembrane transporter activity
GO:0030424 axon
GO:0030426 growth cone
GO:0030544 Hsp70 protein binding
GO:0031115 negative regulation of microtubule polymerization
GO:0031623 receptor internalization
GO:0031648 protein destabilization
GO:0032026 response to magnesium ion
GO:0032410 negative regulation of transporter activity
GO:0032496 response to lipopolysaccharide
GO:0032769 negative regulation of monooxygenase activity
GO:0032991 protein-containing complex
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034341 response to interferon-gamma
GO:0034599 cellular response to oxidative stress
GO:0035067 negative regulation of histone acetylation
GO:0035493 SNARE complex assembly
GO:0035543 positive regulation of SNARE complex assembly
GO:0042393 histone binding
GO:0042416 dopamine biosynthetic process
GO:0042802 identical protein binding
GO:0043014 alpha-tubulin binding
GO:0043025 neuronal cell body
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043679 axon terminus
GO:0045807 positive regulation of endocytosis
GO:0045920 negative regulation of exocytosis
GO:0045921 positive regulation of exocytosis
GO:0048156 tau protein binding
GO:0048471 perinuclear region of cytoplasm
GO:0048488 synaptic vesicle endocytosis
GO:0050729 positive regulation of inflammatory response
GO:0050808 synapse organization
GO:0051219 phosphoprotein binding
GO:0051262 protein tetramerization
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0051583 dopamine uptake involved in synaptic transmission
GO:0051585 negative regulation of dopamine uptake involved in synaptic transmission
GO:0051612 negative regulation of serotonin uptake
GO:0051621 regulation of norepinephrine uptake
GO:0051622 negative regulation of norepinephrine uptake
GO:0060732 positive regulation of inositol phosphate biosynthetic process
GO:0070495 negative regulation of thrombin-activated receptor signaling pathway
GO:0070555 response to interleukin-1
GO:0070840 dynein complex binding
GO:0071280 cellular response to copper ion
GO:0071872 cellular response to epinephrine stimulus
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0097435 supramolecular fiber organization
GO:0099512 supramolecular fiber
GO:1901214 regulation of neuron death
GO:1901215 negative regulation of neuron death
GO:1901216 positive regulation of neuron death
GO:1902957 negative regulation of mitochondrial electron transport, NADH to ubiquinone
GO:1903136 cuprous ion binding
GO:1903284 positive regulation of glutathione peroxidase activity
GO:1903285 positive regulation of hydrogen peroxide catabolic process
GO:1903421 regulation of synaptic vesicle recycling
GO:1903426 regulation of reactive oxygen species biosynthetic process
GO:1904715 negative regulation of chaperone-mediated autophagy
GO:1905606 regulation of presynapse assembly
GO:1990000 amyloid fibril formation

Subcellular Location

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Subcellular Location
Cell junction
Cytoplasm
Membrane
Nucleus
Secreted

Domains

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DomainNameCategoryType
IPR001058 SynucleinFamilyFamily
IPR002460 Alpha-synucleinFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB02709 ResveratrolDrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule