Entity Details

Primary name BRCA1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP38398
EntryNameBRCA1_HUMAN
FullNameBreast cancer type 1 susceptibility protein
TaxID9606
Evidenceevidence at protein level
Length1863
SequenceStatuscomplete
DateCreated1994-10-01
DateModified2021-06-02

Ontological Relatives

GenesBRCA1

GO terms

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GOName
GO:0000151 ubiquitin ligase complex
GO:0000724 double-strand break repair via homologous recombination
GO:0000729 DNA double-strand break processing
GO:0000800 lateral element
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0003713 transcription coactivator activity
GO:0003723 RNA binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0006260 DNA replication
GO:0006301 postreplication repair
GO:0006302 double-strand break repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006349 regulation of gene expression by genetic imprinting
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006633 fatty acid biosynthetic process
GO:0006974 cellular response to DNA damage stimulus
GO:0007059 chromosome segregation
GO:0007098 centrosome cycle
GO:0008270 zinc ion binding
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009048 dosage compensation by inactivation of X chromosome
GO:0010212 response to ionizing radiation
GO:0010575 positive regulation of vascular endothelial growth factor production
GO:0010628 positive regulation of gene expression
GO:0015631 tubulin binding
GO:0016567 protein ubiquitination
GO:0016579 protein deubiquitination
GO:0016604 nuclear body
GO:0019899 enzyme binding
GO:0031398 positive regulation of protein ubiquitination
GO:0031436 BRCA1-BARD1 complex
GO:0031625 ubiquitin protein ligase binding
GO:0032991 protein-containing complex
GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway
GO:0035066 positive regulation of histone acetylation
GO:0035067 negative regulation of histone acetylation
GO:0043009 chordate embryonic development
GO:0043627 response to estrogen
GO:0044030 regulation of DNA methylation
GO:0044818 mitotic G2/M transition checkpoint
GO:0045717 negative regulation of fatty acid biosynthetic process
GO:0045739 positive regulation of DNA repair
GO:0045766 positive regulation of angiogenesis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046600 negative regulation of centriole replication
GO:0051571 positive regulation of histone H3-K4 methylation
GO:0051572 negative regulation of histone H3-K4 methylation
GO:0051573 negative regulation of histone H3-K9 methylation
GO:0051574 positive regulation of histone H3-K9 methylation
GO:0051865 protein autoubiquitination
GO:0070063 RNA polymerase binding
GO:0070317 negative regulation of G0 to G1 transition
GO:0070512 positive regulation of histone H4-K20 methylation
GO:0070531 BRCA1-A complex
GO:0071356 cellular response to tumor necrosis factor
GO:0071681 cellular response to indole-3-methanol
GO:0085020 protein K6-linked ubiquitination
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1990904 ribonucleoprotein complex
GO:2000378 negative regulation of reactive oxygen species metabolic process
GO:2000617 positive regulation of histone H3-K9 acetylation
GO:2000620 positive regulation of histone H4-K16 acetylation

Subcellular Location

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Subcellular Location
Chromosome
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001357 BRCT domainDomainDomain
IPR001841 Zinc finger, RING-typeDomainDomain
IPR011364 Breast cancer type 1 susceptibility protein (BRCA1)FamilyFamily
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR017907 Zinc finger, RING-type, conserved siteSiteConserved site
IPR018957 Zinc finger, C3HC4 RING-typeDomainDomain
IPR025994 BRCA1, serine-rich domainDomainDomain
IPR031099 BRCA1-associatedFamilyFamily
IPR036420 BRCT domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

5 interactions