Entity Details

Primary name IL6RB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP40189
EntryNameIL6RB_HUMAN
FullNameInterleukin-6 receptor subunit beta
TaxID9606
Evidenceevidence at protein level
Length918
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesIL6ST

GO terms

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GOName
GO:0002675 positive regulation of acute inflammatory response
GO:0002821 positive regulation of adaptive immune response
GO:0004896 cytokine receptor activity
GO:0004897 ciliary neurotrophic factor receptor activity
GO:0004921 interleukin-11 receptor activity
GO:0005127 ciliary neurotrophic factor receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005896 interleukin-6 receptor complex
GO:0005900 oncostatin-M receptor complex
GO:0005977 glycogen metabolic process
GO:0008284 positive regulation of cell population proliferation
GO:0009897 external side of plasma membrane
GO:0010575 positive regulation of vascular endothelial growth factor production
GO:0010613 positive regulation of cardiac muscle hypertrophy
GO:0016020 membrane
GO:0016032 viral process
GO:0019221 cytokine-mediated signaling pathway
GO:0019838 growth factor binding
GO:0019955 cytokine binding
GO:0019970 interleukin-11 binding
GO:0030425 dendrite
GO:0034097 response to cytokine
GO:0038165 oncostatin-M-mediated signaling pathway
GO:0042102 positive regulation of T cell proliferation
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042802 identical protein binding
GO:0043025 neuronal cell body
GO:0043066 negative regulation of apoptotic process
GO:0043235 receptor complex
GO:0045509 interleukin-27 receptor activity
GO:0045669 positive regulation of osteoblast differentiation
GO:0045747 positive regulation of Notch signaling pathway
GO:0048711 positive regulation of astrocyte differentiation
GO:0048861 leukemia inhibitory factor signaling pathway
GO:0060576 intestinal epithelial cell development
GO:0070062 extracellular exosome
GO:0070102 interleukin-6-mediated signaling pathway
GO:0070104 negative regulation of interleukin-6-mediated signaling pathway
GO:0070106 interleukin-27-mediated signaling pathway
GO:0070110 ciliary neurotrophic factor receptor complex
GO:0070120 ciliary neurotrophic factor-mediated signaling pathway
GO:0070757 interleukin-35-mediated signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Secreted

Domains

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DomainNameCategoryType
IPR003529 Long hematopoietin receptor, Gp130 family 2, conserved siteSiteConserved site
IPR003961 Fibronectin type IIIDomainDomain
IPR010457 Immunoglobulin C2-set-like, ligand-bindingDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR015321 Type I cytokine receptor, cytokine-binding domainDomainDomain
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
IL6RB_HUMANSTAT3_MOUSEIntAct, MINT10982829 8662591 details
IL6RB_HUMANLMO4_MOUSEBioGRID15677447 details