Entity Details

Primary name VHL_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP40337
EntryNameVHL_HUMAN
FullNamevon Hippel-Lindau disease tumor suppressor
TaxID9606
Evidenceevidence at protein level
Length213
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesVHL

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000902 cell morphogenesis
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0006355 regulation of transcription, DNA-templated
GO:0006508 proteolysis
GO:0008134 transcription factor binding
GO:0008285 negative regulation of cell population proliferation
GO:0010629 negative regulation of gene expression
GO:0016020 membrane
GO:0016567 protein ubiquitination
GO:0019899 enzyme binding
GO:0043066 negative regulation of apoptotic process
GO:0043687 post-translational protein modification
GO:0045597 positive regulation of cell differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT
GO:0050821 protein stabilization
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0061428 negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:1990756 ubiquitin ligase-substrate adaptor activity

Subcellular Location

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Subcellular Location
Cytoplasm
Membrane
Nucleus

Domains

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DomainNameCategoryType
IPR002714 von Hippel-Lindau tumour suppressor proteinFamilyFamily
IPR022772 von Hippel-Lindau disease tumour suppressor, beta/alpha domainDomainDomain
IPR024048 von Hippel-Lindau disease tumour suppressor, alpha domainDomainDomain
IPR024053 von Hippel-Lindau disease tumour suppressor, beta domainDomainDomain
IPR036208 VHL superfamilyFamilyHomologous superfamily
IPR037139 von Hippel-Lindau disease tumour suppressor, alpha domain superfamilyFamilyHomologous superfamily
IPR037140 von Hippel-Lindau disease tumour suppressor, beta domain superfamilyFamilyHomologous superfamily

Diseases

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