Entity Details

Primary name UBP8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP40818
EntryNameUBP8_HUMAN
FullNameUbiquitin carboxyl-terminal hydrolase 8
TaxID9606
Evidenceevidence at protein level
Length1118
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesUSP8

GO terms

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GOName
GO:0000281 mitotic cytokinesis
GO:0004197 cysteine-type endopeptidase activity
GO:0004843 thiol-dependent deubiquitinase
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005829 cytosol
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007032 endosome organization
GO:0007265 Ras protein signal transduction
GO:0014069 postsynaptic density
GO:0016579 protein deubiquitination
GO:0017124 SH3 domain binding
GO:0019897 extrinsic component of plasma membrane
GO:0030496 midbody
GO:0031313 extrinsic component of endosome membrane
GO:0031647 regulation of protein stability
GO:0032880 regulation of protein localization
GO:0043197 dendritic spine
GO:0045296 cadherin binding
GO:0070536 protein K63-linked deubiquitination
GO:0071108 protein K48-linked deubiquitination
GO:0071549 cellular response to dexamethasone stimulus
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0098978 glutamatergic synapse
GO:0099576 regulation of protein catabolic process at postsynapse, modulating synaptic transmission
GO:1990090 cellular response to nerve growth factor stimulus

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Endosome membrane
Nucleus

Domains

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DomainNameCategoryType
IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolaseDomainDomain
IPR001763 Rhodanese-like domainDomainDomain
IPR015063 USP8 dimerisation domainDomainDomain
IPR018200 Ubiquitin specific protease, conserved siteSiteConserved site
IPR028889 Ubiquitin specific protease domainDomainDomain
IPR036873 Rhodanese-like domain superfamilyFamilyHomologous superfamily
IPR038765 Papain-like cysteine peptidase superfamilyFamilyHomologous superfamily

Diseases

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Interactions

3 interactions