Entity Details

Primary name ECHA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP40939
EntryNameECHA_HUMAN
FullNameTrifunctional enzyme subunit alpha, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length763
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesHADHA

GO terms

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GOName
GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity
GO:0003985 acetyl-CoA C-acetyltransferase activity
GO:0004300 enoyl-CoA hydratase activity
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0006635 fatty acid beta-oxidation
GO:0016507 mitochondrial fatty acid beta-oxidation multienzyme complex
GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity
GO:0035965 cardiolipin acyl-chain remodeling
GO:0042645 mitochondrial nucleoid
GO:0070403 NAD+ binding

Subcellular Location

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Subcellular Location
Mitochondrion
Mitochondrion inner membrane

Domains

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DomainNameCategoryType
IPR001753 Enoyl-CoA hydratase/isomeraseFamilyFamily
IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminalDomainDomain
IPR006176 3-hydroxyacyl-CoA dehydrogenase, NAD bindingDomainDomain
IPR006180 3-hydroxyacyl-CoA dehydrogenase, conserved siteSiteConserved site
IPR008927 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamilyFamilyHomologous superfamily
IPR012803 Fatty acid oxidation complex, alpha subunit, mitochondrialFamilyFamily
IPR018376 Enoyl-CoA hydratase/isomerase, conserved siteSiteConserved site
IPR029045 ClpP/crotonase-like domain superfamilyFamilyHomologous superfamily
IPR036291 NAD(P)-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00157 NADHDrugbanksmall molecule

Interactions

0 interactions

InteractorPartnerSourcesPublicationsLink