Entity Details

Primary name CSK_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP41240
EntryNameCSK_HUMAN
FullNameTyrosine-protein kinase CSK
TaxID9606
Evidenceevidence at protein level
Length450
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesCSK

GO terms

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GOName
GO:0002250 adaptive immune response
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0006468 protein phosphorylation
GO:0007420 brain development
GO:0008022 protein C-terminus binding
GO:0008285 negative regulation of cell population proliferation
GO:0010989 negative regulation of low-density lipoprotein particle clearance
GO:0019221 cytokine-mediated signaling pathway
GO:0019903 protein phosphatase binding
GO:0031295 T cell costimulation
GO:0032715 negative regulation of interleukin-6 production
GO:0033673 negative regulation of kinase activity
GO:0034236 protein kinase A catalytic subunit binding
GO:0034332 adherens junction organization
GO:0042802 identical protein binding
GO:0042997 negative regulation of Golgi to plasma membrane protein transport
GO:0043406 positive regulation of MAP kinase activity
GO:0045121 membrane raft
GO:0045779 negative regulation of bone resorption
GO:0046777 protein autophosphorylation
GO:0046872 metal ion binding
GO:0048709 oligodendrocyte differentiation
GO:0050765 negative regulation of phagocytosis
GO:0050852 T cell receptor signaling pathway
GO:0060368 regulation of Fc receptor mediated stimulatory signaling pathway
GO:0070062 extracellular exosome
GO:0070064 proline-rich region binding
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0071375 cellular response to peptide hormone stimulus

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR035027 CSK-like, SH2 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01254 DasatinibDrugbanksmall molecule
DB02010 StaurosporineDrugbanksmall molecule
DB05075 TG-100801Drugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
CSK_HUMANDOK3_MOUSEMINT14993273 details