Entity Details

Primary name PK3CA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP42336
EntryNamePK3CA_HUMAN
FullNamePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
TaxID9606
Evidenceevidence at protein level
Length1068
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesPIK3CA

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001525 angiogenesis
GO:0001889 liver development
GO:0001944 vasculature development
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005942 phosphatidylinositol 3-kinase complex
GO:0005943 phosphatidylinositol 3-kinase complex, class IA
GO:0005944 phosphatidylinositol 3-kinase complex, class IB
GO:0006006 glucose metabolic process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007411 axon guidance
GO:0010468 regulation of gene expression
GO:0010592 positive regulation of lamellipodium assembly
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014704 intercalated disc
GO:0016020 membrane
GO:0016242 negative regulation of macroautophagy
GO:0016301 kinase activity
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0016310 phosphorylation
GO:0016477 cell migration
GO:0019221 cytokine-mediated signaling pathway
GO:0030027 lamellipodium
GO:0030036 actin cytoskeleton organization
GO:0030168 platelet activation
GO:0030295 protein kinase activator activity
GO:0030835 negative regulation of actin filament depolymerization
GO:0031295 T cell costimulation
GO:0032008 positive regulation of TOR signaling
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0035004 phosphatidylinositol 3-kinase activity
GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0035994 response to muscle stretch
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase
GO:0038084 vascular endothelial growth factor signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0038128 ERBB2 signaling pathway
GO:0040014 regulation of multicellular organism growth
GO:0043276 anoikis
GO:0043457 regulation of cellular respiration
GO:0043491 protein kinase B signaling
GO:0043524 negative regulation of neuron apoptotic process
GO:0043542 endothelial cell migration
GO:0043560 insulin receptor substrate binding
GO:0044029 hypomethylation of CpG island
GO:0046854 phosphatidylinositol phosphate biosynthetic process
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048471 perinuclear region of cytoplasm
GO:0050852 T cell receptor signaling pathway
GO:0050900 leukocyte migration
GO:0051897 positive regulation of protein kinase B signaling
GO:0052742 phosphatidylinositol kinase activity
GO:0052812 phosphatidylinositol-3,4-bisphosphate 5-kinase activity
GO:0055119 relaxation of cardiac muscle
GO:0060048 cardiac muscle contraction
GO:0060612 adipose tissue development
GO:0071333 cellular response to glucose stimulus
GO:0071464 cellular response to hydrostatic pressure
GO:0086003 cardiac muscle cell contraction
GO:0097009 energy homeostasis
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:0110053 regulation of actin filament organization
GO:2000270 negative regulation of fibroblast apoptotic process
GO:2000653 regulation of genetic imprinting
GO:2000811 negative regulation of anoikis

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domainDomainDomain
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domainDomainDomain
IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domainDomainDomain
IPR002420 C2 phosphatidylinositol 3-kinase-type domainDomainDomain
IPR003113 Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domainDomainDomain
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR015433 Phosphatidylinositol kinaseFamilyFamily
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR018936 Phosphatidylinositol 3/4-kinase, conserved siteSiteConserved site
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily
IPR036940 Phosphatidylinositol 3-/4-kinase, catalytic domain superfamilyFamilyHomologous superfamily
IPR037704 PI3Kalpha, catalytic domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00171 ATPDrugbanksmall molecule
DB00201 CaffeineDrugbanksmall molecule
DB05241 XL765Drugbanksmall molecule
DB08059 WortmanninDrugbanksmall molecule
DB11772 PilaralisibDrugbanksmall molecule
DB12015 AlpelisibDrugbanksmall molecule
DB12483 CopanlisibDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
PK3CA_HUMANAPC7_MOUSEBioGRID, IntAct20368287 details