Entity Details

Primary name EPS15_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP42566
EntryNameEPS15_HUMAN
FullNameEpidermal growth factor receptor substrate 15
TaxID9606
Evidenceevidence at protein level
Length896
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesEPS15

GO terms

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GOName
GO:0001921 positive regulation of receptor recycling
GO:0005509 calcium ion binding
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005905 clathrin-coated pit
GO:0006895 Golgi to endosome transport
GO:0006897 endocytosis
GO:0009925 basal plasma membrane
GO:0016020 membrane
GO:0016050 vesicle organization
GO:0016197 endosomal transport
GO:0016235 aggresome
GO:0016324 apical plasma membrane
GO:0017124 SH3 domain binding
GO:0019065 receptor-mediated endocytosis of virus by host cell
GO:0030132 clathrin coat of coated pit
GO:0031593 polyubiquitin modification-dependent protein binding
GO:0031901 early endosome membrane
GO:0032456 endocytic recycling
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0042127 regulation of cell population proliferation
GO:0043231 intracellular membrane-bounded organelle
GO:0045296 cadherin binding
GO:0046718 viral entry into host cell
GO:0048268 clathrin coat assembly
GO:0061024 membrane organization
GO:0098794 postsynapse
GO:0098884 postsynaptic neurotransmitter receptor internalization
GO:0098978 glutamatergic synapse

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Early endosome membrane
Membrane

Domains

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DomainNameCategoryType
IPR000261 EH domainDomainDomain
IPR002048 EF-hand domainDomainDomain
IPR003903 Ubiquitin interacting motifSiteConserved site
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR018247 EF-Hand 1, calcium-binding siteSiteBinding site

Diseases

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Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
EPS15_HUMANFCHO2_MOUSEBioGRID, UniProt20448150 details
EPS15_HUMANDAB2_MOUSEBioGRID, UniProt22323290 22648170 details
EPS15_HUMANNUMB_MOUSEBioGRID, IntAct23211419 details