Entity Details

Primary name ABL2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP42684
EntryNameABL2_HUMAN
FullNameTyrosine-protein kinase ABL2
TaxID9606
Evidenceevidence at protein level
Length1182
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesABL2

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0001784 phosphotyrosine residue binding
GO:0003785 actin monomer binding
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005829 cytosol
GO:0006464 cellular protein modification process
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0010506 regulation of autophagy
GO:0010863 positive regulation of phospholipase C activity
GO:0010976 positive regulation of neuron projection development
GO:0015629 actin cytoskeleton
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0030100 regulation of endocytosis
GO:0030145 manganese ion binding
GO:0030155 regulation of cell adhesion
GO:0035024 negative regulation of Rho protein signal transduction
GO:0035640 exploration behavior
GO:0051015 actin filament binding
GO:0051353 positive regulation of oxidoreductase activity
GO:0071300 cellular response to retinoic acid
GO:2000145 regulation of cell motility
GO:2000249 regulation of actin cytoskeleton reorganization

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR015015 F-actin bindingDomainDomain
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR035837 Tyrosine-protein kinase ABL, SH2 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00171 ATPDrugbanksmall molecule
DB01254 DasatinibDrugbanksmall molecule
DB05184 XL228Drugbanksmall molecule
DB07664 K-00546Drugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
ABL2_HUMANMBP_MOUSEBioGRID, MINT18067320 details