Entity Details

Primary name THIM_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP42765
EntryNameTHIM_HUMAN
FullName3-ketoacyl-CoA thiolase, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length397
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesACAA2

GO terms

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GOName
GO:0003723 RNA binding
GO:0003985 acetyl-CoA C-acetyltransferase activity
GO:0003986 acetyl-CoA hydrolase activity
GO:0003988 acetyl-CoA C-acyltransferase activity
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0006635 fatty acid beta-oxidation
GO:0006695 cholesterol biosynthetic process
GO:0016290 palmitoyl-CoA hydrolase activity
GO:0047617 acyl-CoA hydrolase activity
GO:0071456 cellular response to hypoxia
GO:0102991 myristoyl-CoA hydrolase activity
GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1902109 negative regulation of mitochondrial membrane permeability involved in apoptotic process

Subcellular Location

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Subcellular Location
Mitochondrion

Domains

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DomainNameCategoryType
IPR002155 ThiolaseFamilyFamily
IPR016039 Thiolase-likeFamilyHomologous superfamily
IPR020610 Thiolase, active siteSiteActive site
IPR020613 Thiolase, conserved siteSiteConserved site
IPR020615 Thiolase, acyl-enzyme intermediate active siteSiteActive site
IPR020616 Thiolase, N-terminalDomainDomain
IPR020617 Thiolase, C-terminalDomainDomain

Diseases

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Interactions

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InteractorPartnerSourcesPublicationsLink