Entity Details

Primary name WASP_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP42768
EntryNameWASP_HUMAN
FullNameWiskott-Aldrich syndrome protein
TaxID9606
Evidenceevidence at protein level
Length502
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesWAS

GO terms

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GOName
GO:0002625 regulation of T cell antigen processing and presentation
GO:0003779 actin binding
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005884 actin filament
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0006952 defense response
GO:0006955 immune response
GO:0007596 blood coagulation
GO:0008064 regulation of actin polymerization or depolymerization
GO:0008154 actin polymerization or depolymerization
GO:0008544 epidermis development
GO:0010591 regulation of lamellipodium assembly
GO:0012506 vesicle membrane
GO:0015629 actin cytoskeleton
GO:0016197 endosomal transport
GO:0017124 SH3 domain binding
GO:0019901 protein kinase binding
GO:0030041 actin filament polymerization
GO:0030048 actin filament-based movement
GO:0030695 GTPase regulator activity
GO:0031267 small GTPase binding
GO:0032488 Cdc42 protein signal transduction
GO:0035861 site of double-strand break
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042110 T cell activation
GO:0042802 identical protein binding
GO:0043274 phospholipase binding
GO:0045335 phagocytic vesicle
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050852 T cell receptor signaling pathway
GO:0051492 regulation of stress fiber assembly
GO:0051497 negative regulation of stress fiber assembly
GO:0065003 protein-containing complex assembly
GO:0070062 extracellular exosome
GO:0071346 cellular response to interferon-gamma
GO:1905168 positive regulation of double-strand break repair via homologous recombination
GO:2000146 negative regulation of cell motility
GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000095 CRIB domainDomainDomain
IPR000697 WH1/EVH1 domainDomainDomain
IPR003124 WH2 domainDomainDomain
IPR011026 Wiscott-Aldrich syndrome protein, C-terminalFamilyHomologous superfamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR027641 Wiskott-Aldrich syndrome proteinFamilyFamily
IPR033927 WASP family, EVH1 domainDomainDomain
IPR036936 CRIB domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01731 (S)-wiskostatinDrugbanksmall molecule

Interactions

4 interactions