Entity Details

Primary name HD_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP42858
EntryNameHD_HUMAN
FullNameHuntingtin
TaxID9606
Evidenceevidence at protein level
Length3142
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesHTT

GO terms

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GOName
GO:0000132 establishment of mitotic spindle orientation
GO:0002039 p53 binding
GO:0005522 profilin binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005776 autophagosome
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005814 centriole
GO:0005829 cytosol
GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
GO:0006915 apoptotic process
GO:0007030 Golgi organization
GO:0016234 inclusion body
GO:0019900 kinase binding
GO:0030424 axon
GO:0030425 dendrite
GO:0030659 cytoplasmic vesicle membrane
GO:0031072 heat shock protein binding
GO:0031587 positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:0031648 protein destabilization
GO:0032991 protein-containing complex
GO:0034452 dynactin binding
GO:0042297 vocal learning
GO:0042802 identical protein binding
GO:0043065 positive regulation of apoptotic process
GO:0043666 regulation of phosphoprotein phosphatase activity
GO:0044325 transmembrane transporter binding
GO:0045505 dynein intermediate chain binding
GO:0045724 positive regulation of cilium assembly
GO:0047496 vesicle transport along microtubule
GO:0048471 perinuclear region of cytoplasm
GO:0048487 beta-tubulin binding
GO:0099111 microtubule-based transport
GO:0099523 presynaptic cytosol
GO:0099524 postsynaptic cytosol
GO:1903599 positive regulation of autophagy of mitochondrion
GO:1904504 positive regulation of lipophagy
GO:1905289 regulation of CAMKK-AMPK signaling cascade
GO:1905337 positive regulation of aggrephagy
GO:2000479 regulation of cAMP-dependent protein kinase activity
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Cytoplasmic vesicle
Early endosome
Nucleus

Domains

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DomainNameCategoryType
IPR000091 HuntingtinFamilyFamily
IPR011989 Armadillo-like helicalFamilyHomologous superfamily
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR024613 Huntingtin, middle-repeatRepeatRepeat
IPR028426 Huntingtin familyFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB09130 CopperDrugbanksmall molecule